Evidence map›Paper›PMID 34797172›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2022

Understanding the molecular basis of cardiomyopathy.

Marie-Louise Bang, Julius Bogomolovas, Ju Chen

Open access · greenAbstract readReview
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Article
  3. Article
  4. Review
  5. DNA damage and repair in cardiomyopathy: mechanisms and therapeutic opportunities.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  6. Article
  7. Potential Contribution ofCardiology research and practice · 2026
    Article
  8. Article
  9. Review
  10. α Protein Kinase 3 Is Essential for Neonatal and Adult Cardiac Function.Journal of the American Heart Association · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Marie-Louise BangInstitute of Genetic and Biomedical Research (IRGB), National Research Council (CNR), Milan Unit, Milan, Italy.ORCID 0000-0001-8859-5034
Julius BogomolovasDivision of Cardiovascular Medicine, Department of Medicine Cardiology, University of California, San Diego, La Jolla, California.ORCID 0000-0001-8344-1909
Ju ChenDivision of Cardiovascular Medicine, Department of Medicine Cardiology, University of California, San Diego, La Jolla, California.ORCID 0000-0001-7674-4776
University of California San Diego · USInstitute of Genetic and Biomedical Research · IT

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
The Role of Cypher and ENH in heartR01HL066100 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2002 to 2015
$5.3M
Protein Kinase Novel 2 (PKN2) in heartR01HL155826 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2021 to 2024
$2.2M
Novel function of a mitochondria phosphatase in cardiac developmentR01HL157119 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2021 to 2024
$2.2M
Nuclear envelope protein LEMD2 in heartR01HL158981 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2021 to 2024
$2.2M
PRDM16 in cardiac developmentR01HL153032 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2020 to 2023
$1.6M
The Cardiac Role of Filamin CR01HL144872 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2019 to 2022
$1.6M
ALPK3 in cardiac function and diseaseR01HL146759 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2019 to 2022
$1.6M
BAG3 in Cardiac function and diseaseR01HL130295 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2016 to 2019
$1.6M
The role of Nexilin in cardiomyocyte and cardiomyopathyR01HL137957 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, JU · 2017 to 2020
$1.6M
NHLBI NIH HHS R01 HL066100NHLBI NIH HHS R01 HL130295NHLBI NIH HHS R01 HL137957NHLBI NIH HHS R01 HL144872NHLBI NIH HHS R01 HL146759NHLBI NIH HHS R01 HL153032NHLBI NIH HHS R01 HL155826NHLBI NIH HHS R01 HL157119NHLBI NIH HHS R01 HL158981NHLBI NIH HHS T32 HL007444
6 · The paper itself

Abstract

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can be caused by mutations in a wide range of proteins located in different cellular compartments. The present review is based on Dr. Ju Chen's 2021 Robert M. Berne Distinguished Lectureship of the American Physiological Society Cardiovascular Section, in which he provided an overview of the current knowledge on the cardiomyopathy-associated proteins that have been studied in his laboratory. The review provides a general summary of the proteins in different compartments of cardiomyocytes associated with cardiomyopathies, with specific focus on the proteins that have been studied in Dr. Chen's laboratory.

Indexed as

AnimalsCardiomyopathiesGenetic HeterogeneityHumansMutationMyocytes, Cardiaccardiomyopathygeneticsmurine modelsprotein mutationstranslational research

Identifiers

PMID34797172
PMCPMC8759964
OpenAlexW3212946734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.