ReviewJournal of the American Geriatrics Society2022
Unexplained anemia of aging: Etiology, health consequences, and diagnostic criteria.
Review in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed.
- Unexplained Anemia of Aging: From Residual Label to Mechanism-Based Syndrome.European journal of haematology · 2026Article
- Vitamin B12 Deficiency Presenting as Anemia and Functional Decline in an Older Adult: A Case Report.Cureus · 2026Article
- Erythrocyte Count, Anemia, and the Human Natural Lifespan Limit: Evidence from the Long Life Family Study.bioRxiv : the preprint server for biology · 2026Article
- Anemia-Related Red Flags as Distinctive Early Indicators for Colorectal Cancer Diagnosis in Older Adults.Journal of clinical medicine · 2026Article
- Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude.Cell metabolism · 2026Article
- Elevated preoperative red cell distribution width and incident anemia after metabolic and bariatric surgery: a cohort study.Frontiers in nutrition · 2026Article
- Prevalence and Risk of Anemia in People With Multiple Sclerosis (MS): A Systematic Review and Meta-Analysis.Anemia · 2026Review
- Anemia, iron deficiency, and blood biomarkers for Alzheimer disease: clinical interpretation and dementia risk stratification.Frontiers in nutrition · 2026Review
- Joint association of low muscle mass and mild anemia with all-cause, cardiovascular and cancer mortality among US middle and older adults.BMC public health · 2025Article
- Getting back on track to meet global anaemia reduction targets: a Lancet Haematology Commission.The Lancet. Haematology · 2025Review
- Red Blood Cells and Human Aging: Exploring Their Biomarker Potential.Diagnostics (Basel, Switzerland) · 2025Review
- Magnitude and determinants of anemia among patients at Garbo Primary Hospital, Somali Region of Ethiopia.Scientific reports · 2025Article
- Realigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies.The lancet. Diabetes & endocrinology · 2025Review
- Modifications in hemoglobin levels associated with age in an outpatient population from northern italy.Scientific reports · 2025Article
- Article
- Evaluating the utility of the HAS-BLED bleeding-estimator tool for transurethral resection of prostate.BJUI compass · 2025Article
- Interrelationships of frailty, hemoglobin, cognition, and depressive symptoms in aging: a path analysis of the ELSI-Brazil study.Cadernos de saude publica · 2025Article
- Crosstalk: Biochemical Signatures and Clinical Implications in Rare Hereditary Hemolytic Anemias (Hereditary Spherocytosis).Current pharmaceutical design · 2025Article
- Association of anemia with hyperadiponectinemia in oldest-old Japanese women who resided at home alone without wheelchair use.Scientific reports · 2024Article
- Erythropoietin levels in geriatric anemia.Journal of family medicine and primary care · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundUp to 15% of people aged 60 and over are anemic, and the prevalence of anemia increases with age. In older men and women, anemia is associated with increases in the risk of death and all-cause hospitalization, poor functional capacity, quality of life, and depression. METHODS AND
resultsWe reviewed the literature describing anemia in aging populations, focusing on the specific diagnostic criteria of anemia and potential causes in older men and women. Even after extensive etiologic workup that involves careful medical history, physical examination, laboratory measurements, and additional studies such as bone marrow biopsy, anemia of aging is unexplained in up to 40% of older patients with anemia. As a result, treatment options remain limited.
conclusionsThe prevalence of unexplained anemia of aging (UAA; also called unexplained anemia of the elderly, UAE), its deleterious impacts on health, physical function, and quality of life, and the lack of effective treatment or therapy guidelines represent a compelling unmet clinical need. In this review and consensus document, we discuss the scope of the problem, possible causes of UAA, diagnostic criteria, and potential treatment options. Because even mild anemia is strongly linked to poor clinical outcomes, it should receive clinical attention rather than simply being considered a normal part of aging.
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