ArticleeLife2021
Sex differences in learning from exploration.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- On the importance of including both sexes in animal studies - insights from home-cage monitoring.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Sex-biased computations underlying differential set shift performance in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Foraging models explain human exploration in uncertain tasks.Nature communications · 2026Article
- Article
- Sex differences in exploration-exploitation strategies during home-cage decision making.bioRxiv : the preprint server for biology · 2026Article
- Uncertainty and reward histories have distinct effects on decisions after wins and losses.Scientific reports · 2026Article
- IntelliCage protocols using incentive-disincentive dual motivation work with male as well as female mice and reveal sex differences in motivated behavior.Frontiers in behavioral neuroscience · 2026Article
- Enhancing Cognitive Reflection in Medical Trainees and Physicians: An EBM-CBL-PBL Integrated Teaching Model.Advances in medical education and practice · 2026Article
- Female rats adopt a safety-first strategy in a high-conflict platform mediated avoidance task.Frontiers in behavioral neuroscience · 2026Article
- Sex differences in task engagement and lapse rate during reward learning.Oxford open neuroscience · 2026Article
- HMM for discovering decision-making dynamics using reinforcement learning experiments.Biostatistics (Oxford, England) · 2025Article
- Pupil size predicts exploration through critical slowing in prefrontal dynamics.Communications biology · 2025Article
- Sex-specific exploration accounts for differences in valence learning in male and female mice.eLife · 2025Article
- Noisy Memory Generates Value in Changing Environments.Adaptive behavior · 2025Article
- Distinct Patterns of Evoked Firing in Engram and Non-Engram Neurons in the Dentate Gyrus of Hippocampal Slices.Hippocampus · 2025Article
- Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Distinct Computational Mechanisms of Uncertainty Processing Explain Opposing Exploratory Behaviors in Anxiety and Apathy.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Deep Learning Improves Parameter Estimation in Reinforcement Learning Models.bioRxiv : the preprint server for biology · 2025Article
- Individual differences in sequential decision-making.bioRxiv : the preprint server for biology · 2025Article
- Pupil size predicts the onset of exploration and changes in prefrontal dynamics.bioRxiv : the preprint server for biology · 2025Article
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5 authors.
Funding
Abstract
Sex-based modulation of cognitive processes could set the stage for individual differences in vulnerability to neuropsychiatric disorders. While value-based decision making processes in particular have been proposed to be influenced by sex differences, the overall correct performance in decision making tasks often show variable or minimal differences across sexes. Computational tools allow us to uncover latent variables that define different decision making approaches, even in animals with similar correct performance. Here, we quantify sex differences in mice in the latent variables underlying behavior in a classic value-based decision making task: a restless two-armed bandit. While male and female mice had similar accuracy, they achieved this performance via different patterns of exploration. Male mice tended to make more exploratory choices overall, largely because they appeared to get 'stuck' in exploration once they had started. Female mice tended to explore less but learned more quickly during exploration. Together, these results suggest that sex exerts stronger influences on decision making during periods of learning and exploration than during stable choices. Exploration during decision making is altered in people diagnosed with addictions, depression, and neurodevelopmental disabilities, pinpointing the neural mechanisms of exploration as a highly translational avenue for conferring sex-modulated vulnerability to neuropsychiatric diagnoses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.