ArticleExperimental biology and medicine (Maywood, N.J.)2022
Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats.
Article in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 13 citations in OpenAlex.
- The first record of biological activities and chemical constituents of different extracts and semi-purified fractions of Bidens aurea (Aiton) Sherff (Asteraceae).BMC complementary medicine and therapies · 2025Article
- Microgreens: Functional Food for Nutrition and Dietary Diversification.Plants (Basel, Switzerland) · 2025Review
- Therapeutic Potential ofFood science & nutrition · 2025Article
- Microgreens: nutritional properties, health benefits, production techniques, and food safety risks.PeerJ · 2025Review
- Emergence of microgreens as a valuable food, current understanding of their market and consumer perception: A review.Food chemistry: X · 2024Review
- Clover microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis of rats.Food science & nutrition · 2023Article
- Microgreens-A Comprehensive Review of Bioactive Molecules and Health Benefits.Molecules (Basel, Switzerland) · 2023Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased environmental pollution and unhealthy lifestyle are blamed for escalated chronic diseases. Exposure to aflatoxins was recently suggested to have a role in the increased incidence of type 2 diabetes mellitus. Diet modification and consumption of different functional food are now gaining attention, especially in diabetes management. This study investigates the effect of a diet containing barley microgreen against diabetes induced by streptozotocin with or without aflatoxin administration in rats. Barley microgreen was rich in 3'-Benzyloxy-5,6,7,4'-tetramethoxyflavone (48.8% of total) followed by 5β,7βH,10α-Eudesm-11-en-1α-ol (18.46%). Streptozotocin injection and/or aflatoxin administration significantly elevated glucose level, decreased insulin level, decreased β-cell function, deteriorated liver and kidney function parameters, and induced oxidative stress in the liver. Histopathology revealed irregular small-sized islets and decreased area % of insulin-positive beta cells in the pancreas, hepatic degeneration, nephropathy, and neuropathy in diabetic and/or aflatoxin administered rats compared to control. Barley microgreen diet fed to diabetic rats with or without aflatoxin alleviated all evaluated parameters. Barley microgreen diet also ameliorated the toxic effect of aflatoxin. In conclusion, exposure to aflatoxin aggravated diabetes and its complication. The incorporation of barley microgreen in the diet was able to control type 2 diabetes mellitus and the improved outcomes observed with barley microgreen treatments involved or occurred in conjunction with improved biomarkers of oxidative stress.
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