Evidence map›Paper›PMID 34796609›Full record

ArticleEMBO reports2022

Viperin-taken down with a pinch of salt.

Soumi Ghosh, E Neil G Marsh

Open access · bronzeAbstract readComment
In one paragraph

Article in EMBO reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Soumi GhoshDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
E Neil G MarshDepartments of Chemistry and Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1713-1683
Massachusetts Institute of Technology · USUniversity of Michigan · US

Funding

Understanding hydrogen atom transfer reactions in enzymesR01GM093088 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARSH, E NEIL · 2010 to 2023
$3.5M
NIGMS NIH HHS R01 GM093088
6 · The paper itself

Abstract

What to eat when you have a cold has always been the subject of much debate and advice, usually informed by very little science. However, in this issue of EMBO Reports, Yuan et al (2021) uncover an intriguing link between a high salt diet and a susceptibility to viral infection. Mice fed on a short-term high salt diet were found to carry a higher viral load than control mice fed a normal diet. The researchers trace this effect back to a salt-induced decrease in cellular levels of the antiviral protein, viperin. More generally, these studies provide further insights into the regulation of proteins involved in the cellular antiviral response.

Indexed as

Oxidoreductases Acting on CH-CH Group DonorsVirus DiseasesAnimalsAntiviral AgentsMiceProteinsAntiviral AgentsOxidoreductases Acting on CH-CH Group DonorsProteins

Identifiers

PMID34796609
PMCPMC8728622
OpenAlexW3213463889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.