ArticleEvolution; international journal of organic evolution2022
Genetic diversity and disease: The past, present, and future of an old idea.
Article in Evolution; international journal of organic evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Article
- A chromosome-level genome for gila trout (Oncorhynchus gilae) provides a novel resource for conservation and management.BMC genomics · 2026Article
- Effect of host background and environmental conditions on disease susceptibility and mortality in the northern bay scallop, Argopecten irradians irradians.Scientific reports · 2026Article
- Changes in biodiversity drive trypanosome infections of wildlife in Panama.One health (Amsterdam, Netherlands) · 2025Article
- Host Co-Occurrence and Population Size Explain Genetic Differentiation and Diversity in Seal Lice.Molecular ecology · 2025Article
- How Population Structure and Nest Membership Shape Pathogen Patterns in Bumble Bees.Molecular ecology · 2025Article
- Serine recombinases are conserved genetic markers of antiphage defense systems.bioRxiv : the preprint server for biology · 2025Article
- How to harness the effects of exudates and microbes that support beneficial plant-plant interactions for sustainable agriculture.PLoS biology · 2025Review
- Whole-Genome Resequencing Provides Novel Insights Into the Genetic Diversity, Population Structure, and Patterns of Runs of Homozygosity in Mud Crab (Evolutionary applications · 2025Article
- Evidence of high genetic diversity among parasite populations in a schistosomiasis hotspot.Microbiology spectrum · 2025Article
- A Simplified and Integrated View of Disease Control in Varietal Mixtures Using the Phytobiome Framework.Plant, cell & environment · 2025Review
- MHC Diversity Across Time and Space.Ecology and evolution · 2025Review
- Experimental adaptation to singular pathogen challenge reduces susceptibility to novel pathogens inCurrent research in insect science · 2025Article
- Article
- Quantifying Genetic Parameters for Blackleg Resistance in Rapeseed: A Comparative Study.Plants (Basel, Switzerland) · 2024Article
- Investigation of genetic diversity using molecular and biochemical markers associated with powdery mildew resistance in different flax (Linum usitatissimum L.) genotypes.BMC plant biology · 2024Article
- Building pyramids against the evolutionary emergence of pathogens.Proceedings. Biological sciences · 2024Article
- Development and evaluation of a novel single nucleotide polymorphism panel for North American bison.Evolutionary applications · 2024Article
- Effects of plant tissue permeability on invasion and population bottlenecks of a phytopathogen.Nature communications · 2024Article
- Rapid evolution of a bacterial parasite during outbreaks in twoEcology and evolution · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Why do infectious diseases erupt in some host populations and not others? This question has spawned independent fields of research in evolution, ecology, public health, agriculture, and conservation. In the search for environmental and genetic factors that predict variation in parasitism, one hypothesis stands out for its generality and longevity: genetically homogeneous host populations are more likely to experience severe parasitism than genetically diverse populations. In this perspective piece, I draw on overlapping ideas from evolutionary biology, agriculture, and conservation to capture the far-reaching implications of the link between genetic diversity and disease. I first summarize the development of this hypothesis and the results of experimental tests. Given the convincing support for the protective effect of genetic diversity, I then address the following questions: (1) Where has this idea been put to use, in a basic and applied sense, and how can we better use genetic diversity to limit disease spread? (2) What new hypotheses does the established disease-diversity relationship compel us to test? I conclude that monitoring, preserving, and augmenting genetic diversity is one of our most promising evolutionarily informed strategies for buffering wild, domesticated, and human populations against future outbreaks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.