ReviewMolecular biotechnology2022
Overview of the Cellular Stress Responses Involved in Fatty Acid Overproduction in E. coli.
Review in Molecular biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
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- Biosynthesis of lanosterol inSynthetic and systems biotechnology · 2025Article
- Inhibitory Mechanisms of Vine Tea Extract and Dihydromyricetin AgainstFoods (Basel, Switzerland) · 2025Article
- The role of lignin in 17β-estradiol biodegradation: insights from cellular characteristics and lipidomics.Microbial cell factories · 2024Article
- Exploring Fatty Acid β-Oxidation Pathways in Bacteria: From General Mechanisms to DSF Signaling and Pathogenicity in Xanthomonas.Current microbiology · 2024Review
- Genetically Encoded Detection of Biosynthetic Protease Inhibitors.ACS synthetic biology · 2023Article
- Effects of Low Temperature Stress on Source-Sink Organs in Wheat and Phosphorus Mitigation Strategies.Frontiers in plant science · 2022Review
- Gut microbiota-derived butyrate selectively interferes with growth of carbapenem-resistantGut microbesArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Research on microbial fatty acid metabolism started in the late 1960s, and till date, various developments have aided in elucidating the fatty acid metabolism in great depth. Over the years, synthesis of microbial fatty acid has drawn industrial attention due to its diverse applications. However, fatty acid overproduction imparts various stresses on its metabolic pathways causing a bottleneck to further increase the fatty acid yields. Numerous strategies to increase fatty acid titres in Escherichia coli by pathway modulation have already been published, but the stress generated during fatty acid overproduction is relatively less studied. Stresses like pH, osmolarity and oxidative stress, not only lower fatty acid titres, but also alter the cell membrane composition, protein expression and membrane fluidity. This review discusses an overview of fatty acid synthesis pathway and presents a panoramic view of various stresses caused due to fatty acid overproduction in E. coli. It also addresses how certain stresses like high temperature and nitrogen limitation can boost fatty acid production. This review paper also highlights the interconnections that exist between these stresses.
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