ArticleBiochemical genetics2022
Integrative Analysis of the Expression of microRNA, Long Noncoding RNA, and mRNA in Osteoarthritis and Construction of a Competing Endogenous Network.
Article in Biochemical genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- A sulfate-arsenical-ferruginous water affects apoptosis, oxidative stress and the gene expression of inflammatory mediators and of a panel of MicroRNA in IL-1β stimulated human osteoarthritic chondrocytes.Frontiers in medicine · 2026Article
- Identification and validation of hub m7G-related genes and infiltrating immune cells in osteoarthritis based on integrated computational and bioinformatics analysis.BMC musculoskeletal disorders · 2025Article
- Article
- MicroRNA as Possible Mediators of the Synergistic Effect of Celecoxib and Glucosamine Sulfate in Human Osteoarthritic Chondrocyte Exposed to IL-1β.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
This study aimed to identify potential core microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and mRNAs in osteoarthritis (OA) to construct a competing endogenous RNA (ceRNA) and co-expression network. Differentially expressed miRNAs (DEMis) in the dataset GSE143514 comprising five OA and three normal tissues were identified using the DEseq package. Core miRNAs were identified as DEMis overlapping with those reported by the human microRNA disease database. LncRNAs were predicted by the miRNA-lncRNA interactions network from the encyclopedia of RNA interactomes (ENCORI). MiRNet and ENCORI were employed to predict the mRNAs which overlapped with the differentially expressed mRNAs from the dataset GSE114007 to obtain overlapping mRNAs. MiRNA-lncRNA and miRNA-mRNA interactions were integrated to construct the ceRNA network. A total of 143 DEMis were identified in OA and normal tissues, from which hsa-miR-451a, hsa-miR-370-5p, hsa-miR-34a-5p, hsa-miR-210-3p, and hsa-miR-101-3p were assessed as core miRNAs using overlapping analyses. These RNAs may represent potential therapeutic targets for the treatment of OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.