SynthesisSocial psychiatry and psychiatric epidemiology2022
Mental disorder and opioid overdose: a systematic review.
Synthesis in Social psychiatry and psychiatric epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Psychosocial factors associated with overdose subsequent to Illicit Drug use: a systematic review and narrative synthesis.Harm reduction journal · 2024Pooled it
- Predictors of fatal and nonfatal overdose after prescription of opioids for chronic pain: a systematic review and meta-analysis of observational studies.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Pooled it
- Review
- Longitudinal Transitions Between Internalizing and Externalizing Symptoms and Associations with Substance Use among US Young Adults, 2016-2023.Epidemiology (Cambridge, Mass.) · 2026Article
- National Trends In US Opioid-Related Hospitalizations, 2016-23.Health affairs (Project Hope) · 2026Article
- Patient Profiles of Buprenorphine Initiators in General Healthcare Settings: A Latent Class Approach.Journal of general internal medicine · 2026Article
- Opioid use after breast cancer in Denmark: a nationwide study of social and clinical factors.Journal of the National Cancer Institute · 2026Article
- US State Policy Contexts and Mental Health Among Working-Age Adults.The Milbank quarterly · 2026Article
- Spatial Patterns of Opioid Overdose Mortality Risk Across Urban, Transitional, and Rural Communities Using Satellite-Derived and Socioeconomic Indicators.Journal of urban health : bulletin of the New York Academy of Medicine · 2026Article
- Early Adverse Experiences and the Likelihood of Substance Use Disorders and Non-Fatal Overdose in Clinical and Community Settings: A Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2026Review
- Association between gabapentinoid treatment, concurrent use with opioid or benzodiazepine and the risk of drug poisoning: A self-controlled case series study.PLoS medicine · 2026Article
- A Novel Index Measure of Housing-Related Risk as a Predictor of Overdose Among Young People Who Inject Drugs and Injection Networks.Journal of urban health : bulletin of the New York Academy of Medicine · 2026Article
- Identifying Sex Differences in Adverse Events Reported on Opioid Drugs in the FDA's Adverse Event Reporting System (FAERS).Pharmaceuticals (Basel, Switzerland) · 2026Article
- "It could bring a lot of help to people that aren't getting help right now": A qualitative analysis of the impact of virtual care on access to primary care for people with opioid use disorder.PLOS digital health · 2026Article
- The use of learning collaboratives to support integrated mental health and opioid use disorder services: lessons from the HEALing Communities Study.Frontiers in psychology · 2026Article
- Healthcare professionals' engagement in palliative care for patients with mental disorders: a meta-synthesis of qualitative studies.Frontiers in psychiatry · 2026Review
- A Comparative Analysis of Opioid Overdose Hospitalizations Pre- and Post-Pandemic: Insights from the National Inpatient Sample Database.Journal of community hospital internal medicine perspectives · 2026Article
- Racial and Ethnic Disparities in Prehospital Restraint Use and Sedation.American journal of preventive medicine · 2025Article
- Epidemiological and clinical characteristics of acute poisoning with the impact of the COVID-19 pandemic: a multicenter retrospective study in Jiangsu province, China from 2017 to 2023.BMC public health · 2025Article
- Gender and Overdose Risk Factors Among Clients Entering Residential Treatment for Opioid Use.Drug and alcohol review · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
purposeThis systematic review summarizes and presents the current state of research quantifying the relationship between mental disorder and overdose for people who use opioids.
methodsThe protocol was published in Open Science Framework. We used the PECOS framework to frame the review question. Studies published between January 1, 2000, and January 4, 2021, from North America, Europe, the United Kingdom, Australia, and New Zealand were systematically identified and screened through searching electronic databases, citations, and by contacting experts. Risk of bias assessments were performed. Data were synthesized using the lumping technique.
resultsOverall, 6512 records were screened and 38 were selected for inclusion. 37 of the 38 studies included in this review show a connection between at least one aspect of mental disorder and opioid overdose. The largest body of evidence exists for internalizing disorders generally and mood disorders specifically, followed by anxiety disorders, although there is also moderate evidence to support the relationship between thought disorders (e.g., schizophrenia, bipolar disorder) and opioid overdose. Moderate evidence also was found for the association between any disorder and overdose.
conclusionNearly all reviewed studies found a connection between mental disorder and overdose, and the evidence suggests that having mental disorder is associated with experiencing fatal and non-fatal opioid overdose, but causal direction remains unclear.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.