Evidence map›Paper›PMID 34796270›Full record

ArticleBMJ open ophthalmology2021

Association between serum soluble fms-like tyrosine kinase-1 and the central choroidal thickness during pregnancy: a prospective study.

Takafumi Suzuki, Tatsuya Inoue, Nozomi Igarashi, Chisato Agata, Atsushi Okubo, Takeshi Nagamatsu, Takayuki Iriyama, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Takafumi SuzukiDepartment of Ophthalmology, Shinseikai Toyama Hospital, Imizu-gun, Toyama, Japan.ORCID 0000-0002-7385-415X
Tatsuya InoueDepartment of Ophthalmology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Nozomi IgarashiDepartment of Ophthalmology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Chisato AgataDepartment of Ophthalmology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Atsushi OkuboDepartment of Ophthalmology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Takeshi NagamatsuDepartment of Obstetrics and Gynecology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Takayuki IriyamaDepartment of Obstetrics and Gynecology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Maiko Maruyama-InoueDepartment of Ophthalmology and Micro-Technology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yasuo YanagiDepartment of Ophthalmology and Micro-Technology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Kazuaki KadonosonoDepartment of Ophthalmology and Micro-Technology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Ryo AsaokaDepartment of Ophthalmology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.ORCID 0000-0001-7182-1912
Keiko AzumaDepartment of Ophthalmology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Ryo ObataDepartment of Ophthalmology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.ORCID 0000-0002-1762-0797
University of Tokyo Hospital · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the association between serum soluble fms-like tyrosine kinase-1 (sFlt-1) and the choroidal structure during the pregnancy. METHODS AND ANALYSIS: This prospective study enrolled 24 eyes of 12 consecutive healthy pregnant women. Each participant was evaluated during the first, second and third trimester of pregnancy and the postpartum period. The central choroidal thickness (CCT) and Choroidal Vascular Index (CVI) were measured using enhanced depth-imaging optical coherence tomography. Moreover, serum sFlt-1 and vascular endothelial growth factor (VEGF) concentrations were measured manually using ELISA. The association between choroidal structural parameters and serum sFlt-1/VEGF was analysed using a linear mixed model.

resultsThe CCT was significantly thicker in the second and third trimester than the postpartum period (p<0.05). In contrast, there was no significant difference in the CVI throughout pregnancy or the postpartum period. Serum sFlt-1 levels were significantly higher during pregnancy than the postpartum period (p<0.05), whereas the serum VEGF levels were significantly lower during pregnancy than the postpartum period (p<0.05). Furthermore, serum sFlt-1 levels were significantly associated with CCT throughout pregnancy (p=0.011, linear mixed model). On the contrary, sFlt-1 levels was not associated with the CVI during the pregnancy.

conclusionOur results suggest that serum sFlt-1 might have an influence on the choroidal thickness during the pregnancy.

Indexed as

choroid

Identifiers

PMID34796270
PMCPMC8573653
OpenAlexW3212027181

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.