Evidence map›Paper›PMID 34796171›Full record

ArticleFrontiers in cell and developmental biology2021

Butyric Acid Protects Against Renal Ischemia-Reperfusion Injury by Adjusting the Treg/Th17 Balance

Zhen Chen, Miaomiao Wang, Shikun Yang, Jian Shi, Tianhao Ji, Wei Ding, Lianghua Jiang, Zhiwen Fan, Jing Chen, Yunjie Lu

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Zhen ChenThe Third Affiliated Hospital of Soochow University, Changzhou, China.
Miaomiao WangThe Third Affiliated Hospital of Soochow University, Changzhou, China.
Shikun YangKey Laboratory of Liver Transplantation, Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Chinese Academy of Medical Sciences, Nanjing, China.
Jian ShiThe Third Affiliated Hospital of Soochow University, Changzhou, China.
Tianhao JiKey Laboratory of Liver Transplantation, Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Chinese Academy of Medical Sciences, Nanjing, China.
Wei DingThe Third Affiliated Hospital of Soochow University, Changzhou, China.
Lianghua JiangThe First People's Hospital of Kunshan, Kunshan, China.
Zhiwen FanDepartment of Pathology, Affiliated Nanjing Drum Tower Hospital of Nanjing University School of Medicine, Nanjing, China.
Jing ChenThe Third Affiliated Hospital of Soochow University, Changzhou, China.
Yunjie LuThe Third Affiliated Hospital of Soochow University, Changzhou, China.
Soochow University · CNJiangsu University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNJiangsu Province Hospital · CNNanjing Drum Tower Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune regulation plays a vital role in ischemia-reperfusion injury (IRI). Butyric acid (BA) has immunomodulatory effects in many diseases, but its immunomodulatory effects during renal IRI are still unclear. Our research shows that BA protected against IRI and significantly improved renal IRI

Indexed as

butyric acidHO-1renal ischemia–reperfusion injurySTAT3Th17Treg

Identifiers

PMID34796171
PMCPMC8593469
OpenAlexW3208404273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.