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ArticleSovremennye tekhnologii v meditsine2021

Diagnostic Capabilities of Islet Autoantibodies in Children with New-Onset Type 1 Diabetes Mellitus and Healthy Siblings.

K G Korneva, L G Strongin, E V Kolbasina, M V Budylina, N V Makeeva, V E Zagainov

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07627230 (Prospective Cohort Study of Genetic, Immunologic, and Environmental Risk Factors for Type 1 Diabetes in Children and Their Healthy Siblings), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07627230 completednot on this map

Prospective Cohort Study of Genetic, Immunologic, and Environmental Risk Factors for Type 1 Diabetes in Children and Their Healthy Siblings

TypeobservationalSponsorPrivolzhsky Research Medical UniversityRan2017 to 2026Enrolled1,034ConditionsType 1 Diabetes Mellitus
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

K G KornevaAssociate Professor, Department of Endocrinology and Internal Medicine; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
L G StronginProfessor, Head of the Department of Endocrinology and Internal Medicine; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
E V KolbasinaPediatric Endocrinologist, Head of the Department of Endocrinology; Nizhny Novgorod Regional Children's Clinical Hospital, 211 Vaneeva St., Nizhny Novgorod, 603136, Russia.
M V BudylinaHead of the Department of Pediatric Endocrinology and Gastroenterology; Republican Children's Clinical Hospital of the Ministry of Health of the Chuvash Republic, 27 Fedora Gladkova St., Cheboksary, 428020, Russia.
N V MakeevaPediatric Endocrinologist, Chief Non-Staff Pediatric Endocrinologist; Children's Republican Clinical Hospital, 10 Meditsinskaya St., Yoshkar-Ola, the Republic of Mari El, 424005, Russia.
V E ZagainovAssociate Professor, Head of the Department of Faculty Surgery and Transplantology Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
Privolzhsky Research Medical University · RUChuvash State University · RUNizhny Novgorod Regional Clinical Hospital named after Semashko · RUVolga State University of Technology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MATERIALS AND

methodsA total of 424 children were evaluated, 260 children with new-onset T1DM and 164 healthy children with brothers and/or sisters with T1DM.Blood tests for a complex of autoantibodies to insulin (IAA), tyrosine phosphatase (IA-2A), zinc transporter 8 (ZnT8A), pancreatic β-cells (ICA), and glutamate decarboxylase (GADA) were conducted in all the subjects with the enzyme immunoassay method.

resultsIt was found that the diagnostic utility of individual autoantibodies is not equal and varies with age. The optimal age groups for the immunological control of the risks of developing type 1 diabetes in healthy siblings were determined. The highest risks were noted with the combination of GADA, ZnT8A, and IA-2A.

conclusionIslet autoantibodies may serve as prognostic markers of the risk of developing type 1 diabetes in healthy siblings.

Indexed as

Diabetes Mellitus, Type 1Islets of LangerhansAutoantibodiesChildGlutamate DecarboxylaseHumansMaleSiblingsAutoantibodiesGlutamate Decarboxylaseimmunological diagnosis of T1DMislet autoantibodiessiblingstype 1 diabetes mellitus

Identifiers

PMID34796016
PMCPMC8596233
OpenAlexW3115182827

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.