ReviewJournal of thoracic disease2021
Respiratory manifestations of Marfan syndrome: a narrative review.
Review in Journal of thoracic disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Latent Vasculopathy of a Peripheral Pulmonary Artery in FBN1-Related Marfan Syndrome.Pathology international · 2026Article
- Could the Phenotypic Outcomes of Genetic Variability in Cells Operating in Mechanically Dynamic Environments be Influenced by a Disrupted "Cell-ECM" Relationship? Using Cystic Fibrosis and Marfan Syndrome as an Example.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Pulmonary Risk Stratification in Open Thoracoabdominal Aortic Aneurysm Repair.Journal of clinical medicine · 2026Article
- Looking beyond the pneumothorax: lessons from a bilateral presentation of Marfan syndrome.AME case reports · 2026Article
- Complete bilateral spontaneous pneumothorax at moderate altitude revealing Marfan syndrome: a case report.AME case reports · 2026Article
- Complete bilateral spontaneous pneumothorax at moderate altitude: emergency preparedness and diagnostic certainty beyond a rare case.AME case reports · 2026Article
- Complete bilateral spontaneous pneumothorax as a sentinel event for Marfan syndrome.AME case reports · 2026Article
- Discovering paracrine regulators of cell type composition from spatial transcriptomics using SPER.Bioinformatics advances · 2026Article
- Bronchomalacia Complication Following a Bentall Procedure in a Patient With Marfan Syndrome.Cureus · 2025Article
- Spontaneous Pneumothorax: A Review of Underlying Etiologies and Diagnostic Imaging Modalities.Tomography (Ann Arbor, Mich.) · 2025Review
- Review
- Pulmonary hemorrhage in a patient with Marfan syndrome.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
- Unique Features of Cardiovascular Involvement and Progression in Children with Marfan Syndrome Justify Dedicated Multidisciplinary Care.Journal of cardiovascular development and disease · 2024Review
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase.Scientific reports · 2023Article
- A patient with pleuroparenchymal fibroelastosis carrying a novelRespiratory medicine case reports · 2023Article
- Aggressive approach for spontaneous pneumothorax treatment in children with Marfan syndrome?Frontiers in pediatrics · 2023Article
- Spontaneous pneumothorax-associated with genetic disorders.Therapeutic advances in respiratory diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe prevalence of Marfan syndrome (MFS) is estimated to be 1 in 10,000 to 15,000 individuals, but the phenotype of MFS may not be apparent and hence its diagnosis may not be considered by clinicians. Furthermore, the effects of MFS on the lungs and breathing are underrecognized despite the high morbidity that can occur. The objective of this Narrative Review is to delineate the molecular consequences of a defective fibrillin-1 protein and the skeletal and lung abnormalities in MFS that may contribute to respiratory compromise. It is important for clinicians to be cognizant of these MFS-associated respiratory conditions, and a contemporaneous review is needed.
backgroundMFS is an autosomal dominant, connective tissue disorder caused by mutations in the
methodsWe searched PubMed for the key words of "Marfan syndrome," "pectus excavatum," and "scoliosis" with that of "lung disease," "breathing", or "respiratory disease." The bibliographies of identified articles were further searched for relevant articles not previously identified. Each relevant article was reviewed by one or more of the authors and a narrative review was composed.
conclusionsThough the classic manifestations of MFS are cardiovascular, skeletal, and ocular,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.