Evidence map›Paper›PMID 34795909›Full record

ArticleJournal of thoracic disease2021

Operative mortality in adult cardiac surgery: is the currently utilized definition justified?

Patrick G Chan, Laura Seese, Edgar Aranda-Michel, Ibrahim Sultan, Thomas G Gleason, Yisi Wang, Floyd Thoma, Arman Kilic

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Journal of thoracic disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07390903 (Global Longitudinal Strain as a Predictor of Difficult Separating From Cardiopulmonary Bypass), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07390903 recruitingnot on this mapstarted 2026, after this paper: background citation

Global Longitudinal Strain as a Predictor of Difficult Separating From Cardiopulmonary Bypass

TypeobservationalSponsorKartal Kosuyolu Yuksek Ihtisas Education and Research HospitalRan2026 to 2026Enrolled213ConditionsCardiopulmonary Bypass, Coronary Artery Bypass, Heart Valve Diseases, EchocardiographyArmsMyocardial strain imaging
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  11. Interhospital variability in 180-day infections following cardiac surgery.The Journal of thoracic and cardiovascular surgery · 2025
    Article
  12. Prognostic value of high-sensitivity cardiac troponin I after isolated non-CABG cardiac surgery.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Postoperative anemia in cardiac surgery patients: a narrative review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024
    Review
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Patrick G ChanDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Laura SeeseDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Edgar Aranda-MichelDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ibrahim SultanDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Thomas G GleasonDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Yisi WangDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Floyd ThomaDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Arman KilicDivision of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
University of Pittsburgh Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study evaluated operative mortalities following adult cardiac surgical operations to determine if this metric remains appropriate for the modern era.

methodsThis was a retrospective review of Society of Thoracic Surgeons (STS) indexed adult cardiac operations that included coronary artery bypass grafting (CABG), aortic valve replacement (AVR), CABG + AVR, mitral valve repair (MVr), CABG + MVr, mitral valve replacement (MVR) and CABG + MVR, performed at a single institution between 2011 and 2017. The primary outcome was the timing and relatedness of operation mortality, as defined by the STS as mortality within 30-day or during the index hospitalization, compared to the index operation. The secondary outcomes evaluated cause of death and the rates of postoperative complications.

resultsA total of 11,190 index cardiac operations were performed during the study period and operative mortality occurred in 246 (2.2%) of patients. The distribution of operative mortalities included 83.7% (n=206) who expired within 30-day while an inpatient, 6.9% (n=17) died within 30-day as an outpatient, 11.2% (n=23) expired after 30-day. The most common causes of operative mortality were cardiac (38.7%, n=92), renal failure (15.6%, n=37), and strokes (13.9%, n=33). Furthermore, 98.4% (n=242) of deaths were attributable to the index operation. Postoperative complications occurred frequently in those with operative mortality, with blood transfusions (80.1%), reoperations (65.0%) and prolonged ventilation (62.2%) being most common.

conclusionsMost of the operative mortalities seemed to be attributable to the index cardiac operation. We believe that the current definition of mortality remains appropriate in the modern era.

Indexed as

aortic valve replacement (AVR)Cardiac surgerycoronary artery bypass grafting (CABG)mitral valve repair (MVr)mitral valve replacement (MVR)operative mortality

Identifiers

PMID34795909
PMCPMC8575804
OpenAlexW3211208754

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.