Evidence map›Paper›PMID 34795841›Full record

ArticleOxidative medicine and cellular longevity2021

System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma.

Jun Hui Xu, Yong Jun Guan, Zhen Dong Qiu, Xin Zhang, Liu Liu Zi, Yu Zhou, Chen Chen, Jia Yu, Yi Chao Zhang, Wei Xing Wang

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jun Hui XuDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.ORCID https://orcid.org/0000-0002-3408-5896
Yong Jun GuanDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Zhen Dong QiuDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Xin ZhangDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.ORCID https://orcid.org/0000-0002-4438-7337
Liu Liu ZiDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.ORCID https://orcid.org/0000-0001-9588-3552
Yu ZhouDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Chen ChenDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Jia YuDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Yi Chao ZhangDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.ORCID https://orcid.org/0000-0001-8593-8089
Wei Xing WangDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China.ORCID https://orcid.org/0000-0002-3854-0083
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is an aggressive malignant tumor with a poor prognosis. Reactive oxygen species (ROS) play an important role in tumors; however, the role of ROS-related genes is still unclear in HCC. Therefore, we analyzed the role of ROS-related genes in HCC via bioinformatics methods. Firstly, a prognosis model was constructed using LASSO Cox regression and multivariate analyses. We also investigated the potential function of the ROS-related genes and the correlation with immune infiltration, tumor stemness, and drug sensitivity. ICGC database was used for validation. Secondly, we further analyzed the role of 11 ROS-related genes in HCC. As a member of ROS gene family, the role of STK25 has remained unclear in HCC. We explored the biological function of STK25 using

Indexed as

Gene Expression Regulation, NeoplasticAdolescentAdultAgedAged, 80 and overAntineoplastic AgentsApoptosisBiomarkers, TumorCarcinoma, HepatocellularCell ProliferationComputational BiologyDrug Resistance, NeoplasmFemaleGene Expression ProfilingHumansLiver NeoplasmsAntineoplastic AgentsBiomarkers, TumorReactive Oxygen Species

Identifiers

PMID34795841
PMCPMC8593590
OpenAlexW3213616420

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.