Evidence map›Paper›PMID 34795721›Full record

ArticleAfrican health sciences2021

Potential anticancer activity of Acetone extracts of

Mxolisi Justice Ndlovu, Victor Patrick Bagla, Matlou Phenius Mokgotho, Marema Ephraim Makgatho, Thabe Moss Matsebatlela

Open access · diamondAbstract read
In one paragraph

Article in African health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Mxolisi Justice NdlovuDepartment of Biochemistry, Microbiology and Biotechnology Faculty of Sciences and Agriculture.
Victor Patrick BaglaDepartment of Biochemistry, Microbiology and Biotechnology Faculty of Sciences and Agriculture.
Matlou Phenius MokgothoDepartment of Biochemistry, Microbiology and Biotechnology Faculty of Sciences and Agriculture.
Marema Ephraim MakgathoDepartment of Pathology and Medical Sciences, Faculty of Health Sciences,University of Limpopo, South Africa.
Thabe Moss MatsebatlelaDepartment of Biochemistry, Microbiology and Biotechnology Faculty of Sciences and Agriculture.
Biotechnology Research Center · IRUniversity of Limpopo · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCervical cancer is common in women in less developed regions of the world. The plant biomolecules can be employed for synergistic activity with chemo- and radiotherapy. This combinations might result in reduced toxicity and increased efficacy of the treatment regimen.

objectivesThe anti-HeLa cells activity of the acetone extracts of

methodsSecondary metabolite detection and antioxidant activity quantification were determined using the DPPH and ferric iron reducing assays. HeLa cell growth inhibition and mechanistics were assessed by employing MTT and Annexin-V flous assays.

resultsObservations revealed the presence of phenolic, flavonoids, tannins steroids and coumarins in all the plants extracts. High amount of total phenolic and flavonoid content were detected in

conclusionObservable concentration dependent cell proliferation inhibition by test materials was exhibited. The leaf extracts from T. cilliata,

Indexed as

AcetoneAntineoplastic Agents, PhytogenicAntioxidantsFemaleHeLa CellsHumansPlant ExtractsUterine Cervical NeoplasmsAcetoneAntineoplastic Agents, PhytogenicAntioxidantsPlant Extractsanticancer activityantioxidant activityMedicinal plants

Identifiers

PMID34795721
PMCPMC8568207
OpenAlexW3192684072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.