ArticleFrontiers in endocrinology2021
U-Shaped Association Between Serum Uric Acid and Short-Term Mortality in Patients With Infective Endocarditis.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 14 citations in OpenAlex.
- Explainable machine learning model reveals its decision-making process in identifying patients with paroxysmal atrial fibrillation at high risk for recurrence after catheter ablation.BMC cardiovascular disorders · 2023Trial
- Serum uric acid and its association with intrauterine insemination outcomes in women with polycystic ovarian syndrome.The Indian journal of medical research · 2026Article
- Mortality predicting models for patients with infective endocarditis: a machine learning approach.BMC medical informatics and decision making · 2025Observational
- Hyperuricemia and associated factors: The case of outpatients at the Bafoussam Regional Hospital- Cameroon, an analytical cross-sectional study.Health science reports · 2024Article
- Association of serum uric acid with all-cause and cardiovascular mortality in obstructive sleep apnea.Scientific reports · 2023Article
- The Therapeutic Effect and the Potential Mechanism of Flavonoids and Phenolics ofMolecules (Basel, Switzerland) · 2022Article
- U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia.Redox biology · 2022Review
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8 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Increased uric acid (UA) levels have been reported to be associated with poor clinical outcomes in several conditions. However, the prognostic value of UA in patients with infective endocarditis (IE) is yet unknown. Methods: A total of 1,117 patients with IE were included and divided into two groups according to the current definition of hyperuricemia (UA>420 μmol/L in men and >360 μmol/L in women): hyperuricemia group (n=336) and normouricemia group (n=781). The association between the UA level and short-term outcomes were examined. Results: The in-hospital mortality was 6.2% (69/1117). Patients with hyperuricemia carried a higher risk of in-hospital death (9.8% Conclusion: The previous definition of hyperuricemia was not suitable for risk assessment in patients with IE because of the U-shaped relationship between UA levels and in-hospital death. Low and high levels of UA were predictive of increased short-term mortality in IE patients.
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