ReviewFrontiers in human neuroscience2021
Future Therapeutic Strategies for Freezing of Gait in Parkinson's Disease.
Review in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Usefulness of Wearable Sensors for Detecting Freezing of Gait in Parkinson's Disease: A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- Pooled it
- Feasibility of a novel eHealth intervention for Parkinson's disease targeting motor-cognitive function in the home.BMC neurology · 2024Trial
- Biomechanical energy harvesting to improve post-stroke mobility.Nature communications · 2026Article
- Aberrant Beta-Band Network Alteration Preceding Freezing of Gait in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Management of freezing of gait - mechanism-based practical recommendations.Nature reviews. Neurology · 2025Review
- Motor, affective, cognitive, and perceptual symptom changes over time in individuals with Parkinson's disease who develop freezing of gait.Journal of neurology · 2025Article
- Freezing of gait detection: The effect of sensor type, position, activities, datasets, and machine learning model.Journal of Parkinson's disease · 2025Article
- A machine learning contest enhances automated freezing of gait detection and reveals time-of-day effects.Nature communications · 2024Article
- High-frequency rTMS over bilateral primary motor cortex improves freezing of gait and emotion regulation in patients with Parkinson's disease: a randomized controlled trial.Frontiers in aging neuroscience · 2024Article
- Soft robotic apparel to avert freezing of gait in Parkinson's disease.Nature medicine · 2024Article
- Effect of dopamine on limbic network connectivity at rest in Parkinson's disease patients with freezing of gait.Translational neuroscience · 2024Article
- Efficacy of exercise interventions combined with Selegiline in ameliorating freezing of gait in Parkinson's disease patients.American journal of translational research · 2024Article
- Is the freezing index a valid outcome to assess freezing of gait during turning in Parkinson's disease?Frontiers in neurology · 2024Article
- A meta-analysis identifies factors predicting the future development of freezing of gait in Parkinson's disease.NPJ Parkinson's disease · 2023Review
- Split-Belt Treadmill Adaptation Improves Spatial and Temporal Gait Symmetry in People with Multiple Sclerosis.Sensors (Basel, Switzerland) · 2023Article
- How resistant are levodopa-resistant axial symptoms? Response of freezing, posture, and voice to increasing levodopa intestinal infusion rates in Parkinson disease.European journal of neurology · 2023Article
- Measurement Accuracy of Freezing of Gait Scoring Based on Videos.Frontiers in human neuroscience · 2022Article
- Genetic architecture of Parkinson's disease subtypes - Review of the literature.Frontiers in aging neuroscience · 2022Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Freezing of gait (FOG) is a common and challenging clinical symptom in Parkinson's disease. In this review, we summarise the recent insights into freezing of gait and highlight the strategies that should be considered to improve future treatment. There is a need to develop individualised and on-demand therapies, through improved detection and wearable technologies. Whilst there already exist a number of pharmacological (e.g., dopaminergic and beyond dopamine), non-pharmacological (physiotherapy and cueing, cognitive training, and non-invasive brain stimulation) and surgical approaches to freezing (i.e., dual-site deep brain stimulation, closed-loop programming), an integrated collaborative approach to future research in this complex area will be necessary to systematically investigate new therapeutic avenues. A review of the literature suggests standardising how gait freezing is measured, enriching patient cohorts for preventative studies, and harnessing the power of existing data, could help lead to more effective treatments for freezing of gait and offer relief to many patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.