ArticleNature neuroscience2021
GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation.
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Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Re-analysis of gene mutations found in pituitary stalk interruption syndrome and a new hypothesis on the etiology.Frontiers in endocrinology · 2024Pooled it
- Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?International journal of molecular sciences · 2026Review
- Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026Review
- Cell-type-specific architecture of the hypothalamus in a socially plastic vertebrate.bioRxiv : the preprint server for biology · 2026Article
- Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation.Reviews in endocrine & metabolic disorders · 2026Review
- Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis.Science (New York, N.Y.) · 2026Article
- Haploinsufficiency of Sox2 causes fewer GnRH neurons and delayed puberty in mice.Endocrinology · 2026Article
- Hypothalamic neuroimmune remodeling as an immunometabolic bridge between childhood obesity and earlier pubertal onset.Frontiers in immunology · 2026Review
- Increase of astrocyte apposition on GnRH neurons in early puberty onset induced by high fat diet.Journal of neuroendocrinology · 2025Article
- GnRH and Cognition.Endocrinology · 2025Review
- EndoCompass Project: Environmental Endocrinology.Hormone research in paediatrics · 2025Review
- Regulating Integrin β1 to Restore Gonadotropin-Releasing Hormone-Tanycyte Unit Function in Polycystic Ovary Syndrome-Related Hypothalamic Dysregulation.Research (Washington, D.C.) · 2025Article
- Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins.Journal of endocrinological investigation · 2024Review
- Kisspeptin signaling in astrocytes modulates the reproductive axis.The Journal of clinical investigation · 2024Article
- Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra's seminal work.Nature reviews. Endocrinology · 2024Review
- Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats.Frontiers in veterinary science · 2024Article
- Hypothalamic Kisspeptin Neurons: Integral Elements of the GnRH System.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Heterozygous mutations in SOX2 may cause idiopathic hypogonadotropic hypogonadism via dominant-negative mechanisms.JCI insight · 2023Article
- Mammalian puberty: a fly perspective.The FEBS journal · 2023Review
- Article
Corrections and comments
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Authors and funding
22 authors at 7 institutions in 5 countries.
Giuliana Pellegrino *Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.
Marion Martin *Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.
Cécile Allet *Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.ORCID http://orcid.org/0000-0003-1294-9064
Tori LhommeUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.
Sarah GellerCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Delphine FranssenNeuroendocrinology Unit, GIGA Neurosciences, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0003-2936-6682
Virginie MansuyService of Endocrinology, Diabetology and Metabolism, University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland.
Maria Manfredi-LozanoUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.
Adrian Coutteau-RoblesUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.
Virginia DelliUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.
S RasikaUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.ORCID http://orcid.org/0000-0001-8733-4641
Danièle MazurUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.
Anne LoyensUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France.
Manuel Tena-SempereDepartment of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain.ORCID http://orcid.org/0000-0002-4741-5567
Juergen SiepmannUniv. Lille, Inserm, CHU Lille, U1008, Lille, France.
François P PralongService of Endocrinology, Diabetology and Metabolism, University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland.
Philippe CiofiInserm U1215, Neurocentre Magendie, Bordeaux, France.
Gabriel CorfasKresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5412-9473
Anne-Simone ParentNeuroendocrinology Unit, GIGA Neurosciences, University of Liège, Liège, Belgium.
Sergio R OjedaDivision of Neuroscience, Oregon National Primate Research Center-Oregon Health & Science University, Beaverton, OR, USA.
Ariane SharifUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France. ariane.sharif@inserm.fr.ORCID http://orcid.org/0000-0003-0810-400X
Vincent PrevotUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, FHU 1000 Days for Health, Lille, France. vincent.prevot@inserm.fr.ORCID http://orcid.org/0000-0001-7185-3615
Inserm · FRUniversity of Liège · BEInstituto de Salud Carlos III · ESOregon National Primate Research Center · USUniversité de Bordeaux · FRUniversity of Lausanne · CHUniversity of Michigan · US
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MMetabolic Control of Puberty: Epigenetic LinksR01HD084542 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI LOMNICZI, ALEJANDRO · 2015 to 2019
$2.6MNICHD NIH HHS R01 HD084542NIH HHS P51 OD011092
Abstract
Neurons that produce gonadotropin-releasing hormone (GnRH), which control fertility, complete their nose-to-brain migration by birth. However, their function depends on integration within a complex neuroglial network during postnatal development. Here, we show that rodent GnRH neurons use a prostaglandin D
Indexed as
Gonadotropin-Releasing HormoneSexual MaturationAstrocytesHypothalamusNeuronsGonadotropin-Releasing Hormone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.