Evidence map›Paper›PMID 34795362›Full record

ArticleScientific reports2021

CD8-positive T cells and CD204-positive M2-like macrophages predict postoperative prognosis of very high-risk prostate cancer.

Yoshinori Yanai, Takeo Kosaka, Shuji Mikami, Hiroshi Hongo, Yota Yasumizu, Toshikazu Takeda, Kazuhiro Matsumoto, Jun Miyauchi, Shigehisa Kitano, Mototsugu Oya

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  8. Loss of phosphatase and tensin homolog expression castration-sensitive prostate cancer predicts outcomes in men after prostatectomy.International journal of urology : official journal of the Japanese Urological Association · 2025
    Article
  9. Article
  10. Review
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  12. Microphysiological systems as models for immunologically 'cold' tumors.Frontiers in cell and developmental biology · 2024
    Review
  13. High CD204Journal of Cancer · 2024
    Article
  14. Review
  15. Dietary fat and lipid metabolism in the tumor microenvironment.Biochimica et biophysica acta. Reviews on cancer · 2023
    Review
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yoshinori YanaiDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Takeo KosakaDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. takemduro@gmail.com.
Shuji MikamiDepartment of Diagnostic Pathology, Keio University School of Medicine, Tokyo, Japan.
Hiroshi HongoDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Yota YasumizuDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Toshikazu TakedaDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Kazuhiro MatsumotoDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Jun MiyauchiDepartment of Diagnostic Pathology, Saitama City Hospital, Saitama, Japan.
Shigehisa KitanoDepartment of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
Mototsugu OyaDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Keio University Hospital · JPKeio University · JPSaitama Municipal Hospital · JPTokyo National Hospital · JP

Funding

Grants-in-Aid for Scientific Research #17K11158Grants-in-Aid for Scientific Research #18K16709
6 · The paper itself

Abstract

To stratify the heterogeneity of prostate cancer (PCa) with seminal vesicle invasion (SVI) immunologically after radical prostatectomy focusing on the tumor microenvironment. We retrospectively reviewed the clinicopathological data of 71 PCa patients with SVI, which is known as a factor of very high-risk PCa. Preoperative clinical variables and postoperative pathological variables were evaluated as predictors of biochemical recurrence (BCR) with a multivariate logistic regression. Immune cell infiltration including the CD8-positive cell (CD8

Indexed as

AgedCD8-Positive T-LymphocytesHumansIncidenceKaplan-Meier EstimateMacrophagesMaleMiddle AgedMultivariate AnalysisNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingPrognosisProstateProstatectomyProstate-Specific AntigenMSR1 protein, humanProstate-Specific AntigenScavenger Receptors, Class A

Identifiers

PMID34795362
PMCPMC8602636
OpenAlexW3182507454

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.