ArticleNature communications2021
G3BP1 inhibits Cul3
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Not only as a Cullin3 ligase adaptor, SPOP may also act as a molecular bridge.Genes & diseases · 2027Review
- G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K-AKT-mTOR Signal Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High-throughput screening identifies a critical role of the SPOP-PABPC1 axis in lung adenocarcinoma progression.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- SPOP-mediated K27-linked non-degradative ubiquitination of KCNN3 suppressing HCC progression via the CTCF-SATB1 axis.Cell death & disease · 2026Article
- Comparative Blood-Based Transcriptomic Profiles of Prostate Cancer Patients from South Africa and the USA: A Cross-Sectional Pilot Study.Journal of Cancer · 2026Article
- Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression.Molecular biomedicine · 2025Article
- Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment.The Journal of clinical investigation · 2025Article
- The role of IGF2BP3/SPOP/c-Myc loop in paclitaxel resistance of endometrial cancer.Communications biology · 2025Article
- Pseudorabies virus IE180 protein hijacks G3BPs into the nucleus to inhibit stress granule formation.Journal of virology · 2025Article
- Cul3 substrate adaptor SPOP targets Nup153 for degradation.Molecular biology of the cell · 2025Article
- Article
- Challenges and opportunities for the diverse substrates of SPOP E3 ubiquitin ligase in cancer.Theranostics · 2025Review
- Targeting mRNA-coding genes in prostate cancer using CRISPR/Cas9 technology with a special focus on androgen receptor signaling.Cell communication and signaling : CCS · 2024Review
- ANO7 African-ancestral genomic diversity and advanced prostate cancer.Prostate cancer and prostatic diseases · 2024Article
- Review
- A new tandem repeat-enriched lncRNA XLOC_008672 promotes gastric carcinogenesis by regulating G3BP1 expression.Cancer science · 2024Article
- G3BP1 Interact with JAK2 mRNA to Promote the Malignant Progression of Nasopharyngeal Carcinoma via Activating JAK2/STAT3 Signaling Pathway.International journal of biological sciences · 2024Article
- Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axis.Cell communication and signaling : CCS · 2023Article
- Role(s) of G3BPs in Human Pathogenesis.The Journal of pharmacology and experimental therapeutics · 2023Review
- LIMK2 promotes melanoma tumor growth and metastasis through G3BP1-ESM1 pathway-mediated apoptosis inhibition.Oncogene · 2023Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Chandrani MukhopadhyayDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10065, USA.
Chenyi YangDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10065, USA.
Limei XuDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10065, USA.
Deli LiuSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0003-4513-5753
Yu WangDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10065, USA.
Dennis HuangDepartment of Urology, Weill Cornell Medicine, New York, NY, 10065, USA.
Lesa Dayal DeonarineSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.
Joanna CyrtaDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10065, USA.
Elai DavicioniGenomeDx Bioscience, Vancouver, BC, Canada.
Andrea SbonerDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0001-6915-3070
Brian D RobinsonDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0001-5374-890X
Arul M ChinnaiyanMichigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8743-7480
Mark A RubinDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-8321-9950
Christopher E BarbieriSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0002-0381-1947
Pengbo ZhouDepartment of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, 10065, USA. pez2001@med.cornell.edu.ORCID http://orcid.org/0000-0002-4912-2901
Cornell University · USGenome British Columbia · CAUniversity of Bern · CHUniversity of Michigan · US
Funding
Weill Cornell Medicine (WCM) SPORE in Prostate CancerP50CA211024 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUDAS, LORRAINE J · 2017 to 2021
$10.9MTowards Understanding Prostate Cancer HeterogeneityR01CA125612 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RUBIN, MARK A. · 2007 to 2017
$3.4MHarnessing the CRL4 ubiquitin ligase for antagonizing colorectal carcinogenesisR01CA213992 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, PENGBO · 2017 to 2021
$2.7MCoordinate Regulation of Oncogenic Signaling Pathways in SPOP Mutant Prostate CancerR37CA215040 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BARBIERI, CHRISTOPHER E · 2018 to 2024
$2.6MG3BP1 Suppresses SPOP Ubiquitin Ligase to Promote Prostate TumorigenesisR01CA221152 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZHOU, PENGBO · 2018 to 2022
$2.4MNCI NIH HHS P50 CA211024NCI NIH HHS R01 CA125612NCI NIH HHS R01 CA213992NCI NIH HHS R01 CA221152NCI NIH HHS R37 CA215040
Abstract
SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key substrates mediating oncogenic function. However, the mechanisms underlying SPOP regulation are largely unknown. Here, we have identified G3BP1 as an interactor of SPOP and functions as a competitive inhibitor of Cul3
Indexed as
Androgen Receptor AntagonistsAnimalsCarcinogenesisCell Line, TumorCell MovementCell SurvivalCullin ProteinsDNA HelicasesGene Expression Regulation, NeoplasticHumansMaleMiceMutationNuclear ProteinsPoly-ADP-Ribose Binding ProteinsProstatic NeoplasmsAndrogen Receptor AntagonistsCUL3 protein, humanCullin ProteinsDNA HelicasesG3BP1 protein, humanNuclear ProteinsPoly-ADP-Ribose Binding ProteinsReceptors, AndrogenRepressor ProteinsRNA HelicasesRNA Recognition Motif ProteinsSPOP protein, humanUbiquitin-Protein Ligases
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