ArticleNature communications2021
Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Backward scrunching: planarians escape from noxious stimuli, cannibalism, and predation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Adhesion and Injury Cues Enhance Blackworm Capture by Freshwater Planaria.Integrative and comparative biology · 2025Article
- Identification of an innexin required for termination of the asexual state in planarian reproductive switching.PLoS genetics · 2025Article
- Article
- Investigating the Functions of Hox Genes Using Planarian Asexual Reproduction.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Nature's Secret Neuro-Regeneration Pathway in Axolotls, Polychaetes and Planarians for Human Therapeutic Target Pathways.International journal of molecular sciences · 2024Review
- The role ofbioRxiv : the preprint server for biology · 2024Article
- Conserved Genes in Highly Regenerative Metazoans Are Associated with Planarian Regeneration.Genome biology and evolution · 2024Article
- The Role ofIntegrative organismal biology (Oxford, England) · 2024Article
- The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration.Zoological research · 2023Review
- Article
- Environmental and molecular regulation of asexual reproduction in the sea anemoneRoyal Society open science · 2023Article
- Environmental and molecular regulation of asexual reproduction in the sea anemone Nematostella vectensis.bioRxiv : the preprint server for biology · 2023Article
- Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.Nature communications · 2023Article
- Hox genes in development and beyond.Development (Cambridge, England) · 2023Article
- Article
- Positional Information and Stem Cells Combine to Result in Planarian Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Hox genes are highly conserved transcription factors renowned for their roles in the segmental patterning of the embryonic anterior-posterior (A/P) axis. We report functions for Hox genes in A/P tissue segmentation and transverse fission behavior underlying asexual reproduction in adult planarian flatworms, Schmidtea mediterranea. Silencing of each of the Hox family members identifies 5 Hox genes required for asexual reproduction. Among these, silencing of hox3 genes results in supernumerary fission segments, while silencing of post2b eliminates segmentation altogether. The opposing roles of hox3 and post2b in segmentation are paralleled in their respective regulation of fission behavior. Silencing of hox3 increases the frequency of fission behavior initiation while silencing of post2b eliminates fission behavior entirely. Furthermore, we identify a network of downstream effector genes mediating Hox gene functions, providing insight into their respective mechanisms of action. In particular, we resolve roles for post2b and effector genes in the functions of the marginal adhesive organ in fission behavior regulation. Collectively, our study establishes adult stage roles for Hox genes in the regulation of tissue segmentation and behavior associated with asexual reproduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.