ArticleNature communications2021
Osseosurface electronics-thin, wireless, battery-free and multimodal musculoskeletal biointerfaces.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Advancements in Machine Learning-Assisted Flexible Electronics: Technologies, Applications, and Future Prospects.Biosensors · 2026Pooled it
- A Geometrically Transient Platform for Bioelectronic Implants.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Instrumentalized 3D printed scaffolds enable bone regeneration and fracture healing monitoring in critical size bone defects.APL bioengineering · 2026Article
- Advances and Challenges in Wearable Sensors for Health Monitoring.ACS applied materials & interfaces · 2026Review
- Toward autonomous robotic-assisted and microrobotic surgery.Science advances · 2026Review
- Robust magnetoelectric backscatter communication system for bioelectronic implants.Communications engineering · 2026Article
- Continuous operation of battery-free implants enables advanced fracture recovery monitoring.Science advances · 2025Article
- Nanoscale heat generation in a single Si nanowire.Nanophotonics (Berlin, Germany) · 2025Article
- An In Vivo Biostability Evaluation of ALD and Parylene-ALD Multilayers as Micro-Packaging Solutions for Small Single-Chip Implants.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Implantable wireless suture sensor for in situ tendon and ligament strain monitoring.Science advances · 2025Article
- Protein design accelerates the development and application of optogenetic tools.Computational and structural biotechnology journal · 2025Review
- Development of an implantable sensor system forBioactive materials · 2025Article
- Perspectives on non-genetic optoelectronic modulation biointerfaces for advancing healthcare.Med-X · 2024Article
- Recent Advances in Transparent Electrodes and Their Multimodal Sensing Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- A Miniaturized Wireless, Battery-free Implant for In Vivo Musculoskeletal Stimulation.The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems · 2024Article
- Can we improve techniques and patients' selection for nerve stimulation suitable for lower urinary tract dysfunctions? ICI-RS 2023.Neurourology and urodynamics · 2024Review
- Ultra-low frequency magnetic energy focusing for highly effective wireless powering of deep-tissue implantable electronic devices.National science review · 2024Article
- Low-impedance tissue-device interface using homogeneously conductive hydrogels chemically bonded to stretchable bioelectronics.Science advances · 2024Article
- The application of impantable sensors in the musculoskeletal system: a review.Frontiers in bioengineering and biotechnology · 2024Review
- Fully implanted battery-free high power platform for chronic spinal and muscular functional electrical stimulation.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Bioelectronic interfaces have been extensively investigated in recent years and advances in technology derived from these tools, such as soft and ultrathin sensors, now offer the opportunity to interface with parts of the body that were largely unexplored due to the lack of suitable tools. The musculoskeletal system is an understudied area where these new technologies can result in advanced capabilities. Bones as a sensor and stimulation location offer tremendous advantages for chronic biointerfaces because devices can be permanently bonded and provide stable optical, electromagnetic, and mechanical impedance over the course of years. Here we introduce a new class of wireless battery-free devices, named osseosurface electronics, which feature soft mechanics, ultra-thin form factor and miniaturized multimodal biointerfaces comprised of sensors and optoelectronics directly adhered to the surface of the bone. Potential of this fully implanted device class is demonstrated via real-time recording of bone strain, millikelvin resolution thermography and delivery of optical stimulation in freely-moving small animal models. Battery-free device architecture, direct growth to the bone via surface engineered calcium phosphate ceramic particles, demonstration of operation in deep tissue in large animal models and readout with a smartphone highlight suitable characteristics for exploratory research and utility as a diagnostic and therapeutic platform.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.