ArticleNature communications2021
Asymmetric radical carboesterification of dienes.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Copper-Catalyzed Amino Radical Transfer-Mediated Deborylation for Chiral Ester Synthesis.Angewandte Chemie (International ed. in English) · 2026Article
- Copper-catalyzed enantioselective synthesis of γ-butenolides via radical diversification of allenoic acid.Nature communications · 2025Article
- Photoinduced Copper-Catalyzed Enantioselective Allylic C(Journal of the American Chemical Society · 2025Article
- Copper-catalyzed enantioselective three-component radical 1,4-perfluoroalkylamination of 1,3-dienes.Nature communications · 2025Article
- Mechanistic insights into nonlinear effects in copper-catalyzed asymmetric esterification.Nature communications · 2025Article
- Enantiopure Turbo Chirality Targets in Tri-Propeller Blades: Design, Asymmetric Synthesis, and Computational Analysis.Molecules (Basel, Switzerland) · 2025Article
- Rapid and scalable photocatalytic C(spNature communications · 2024Article
- Enantioenriched Allylesters via a Copper-Catalyzed Diene Carboesterification with Alkyltrifluoroborates and Carboxylic Acids.The Journal of organic chemistry · 2024Article
- Dealkenylative Functionalizations: Conversion of Alkene C(spSynthesis · 2024Article
- Recent Advances in the Enantioselective Radical Reactions.Molecules (Basel, Switzerland) · 2023Review
- The potential of converting carbon dioxide to food compoundsNanoscale advances · 2023Review
- When all C-C breaks LO-Ose.Trends in chemistry · 2023Article
- Radical transformations for allene synthesis.Chemical science · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The straightforward strategy of building a chiral C-O bond directly on a general carbon radical center is challenging and stereocontrol of the reactions of open-chain hydrocarbon radicals remains a largely unsolved problem. Advance in this elementary step will spur the development of asymmetric radical C-O bond construction. Herein, we report a copper-catalyzed regioselective and enantioselective carboesterification of substituted dienes using alkyl diacyl peroxides as the source of both the carbon and oxygen substituents. The participation of external acids in this reaction substantially extends its applicability and leads to structurally diverse allylic ester products. This work represents the advance in the key elementary reaction of intermolecular enantioselective construction of C-O bond on open-chain hydrocarbon radicals and may lead to the discovery of other asymmetric radical reactions.
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