Evidence map›Paper›PMID 34795206›Full record

ArticleSignal transduction and targeted therapy2021

Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer.

Yaohui Gao, Dexi Bi, Ruting Xie, Man Li, Jing Guo, Hu Liu, Xianling Guo, Juemin Fang, Tingting Ding, Huiyuan Zhu and 7 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 200 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 3 pooled it
25.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 3 syntheses or guidelines pooled it, 273 citations in OpenAlex.

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  15. Harnessing the microbiome for cancer therapy.Nature reviews. Microbiology · 2026
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140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Yaohui Gao *Department of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Dexi Bi *Department of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Ruting Xie *Department of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Man LiDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Jing GuoDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Hu LiuDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Xianling GuoDepartment of Oncology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Juemin FangDepartment of Oncology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Tingting DingDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Huiyuan ZhuDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Yuan CaoDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Meichun XingDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Jiayi ZhengDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Qing XuDepartment of Oncology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Qian XuDepartment of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China.
Qing WeiDepartment of Pathology, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China. weiqing1971@tongji.edu.cn.
Huanlong QinDepartment of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, 200072, Shanghai, China. qinhuanlong@tongji.edu.cn.
Tongji University · CNShanghai Tenth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given that only a subset of patients with colorectal cancer (CRC) benefit from immune checkpoint therapy, efforts are ongoing to identify markers that predict immunotherapeutic response. Increasing evidence suggests that microbes influence the efficacy of cancer therapies. Fusobacterium nucleatum induces different immune responses in CRC with different microsatellite-instability (MSI) statuses. Here, we investigated the effect of F. nucleatum on anti-PD-L1 therapy in CRC. We found that high F. nucleatum levels correlate with improved therapeutic responses to PD-1 blockade in patients with CRC. Additionally, F. nucleatum enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged survival. Combining F. nucleatum supplementation with immunotherapy rescued the therapeutic effects of PD-L1 blockade. Furthermore, F. nucleatum induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma (IFN-γ)

Indexed as

Colorectal NeoplasmsAnimalsB7-H1 AntigenCaco-2 CellsCD8-Positive T-LymphocytesFusobacterium nucleatumHumansImmune Checkpoint InhibitorsMiceNeoplasm ProteinsB7-H1 AntigenCD274 protein, humanCd274 protein, mouseImmune Checkpoint InhibitorsNeoplasm Proteins

Identifiers

PMID34795206
PMCPMC8602417
OpenAlexW3213342404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.