ArticleProceedings of the National Academy of Sciences of the United States of America2021
Cone photoreceptor dysfunction in retinitis pigmentosa revealed by optoretinography.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed, 100 citations in OpenAlex.
- Use of a Retinal Phantom to Facilitate Adaptive Optics Scanning Light Ophthalmoscopy Imaging in a Multicenter Clinical Trial.Translational vision science & technology · 2026Trial
- Spatio-temporal optical coherence imaging and tomography forJournal of biomedical optics · 2026Review
- Proto-clinical optoretinography dependence on temporal and spatial resolution.Biomedical optics express · 2026Article
- Cis- and Trans-Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- In vivo elastography of the human retina using light-evoked intrinsic actuation.bioRxiv : the preprint server for biology · 2026Article
- Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response.bioRxiv : the preprint server for biology · 2026Article
- Phase-based optoretinographic measurements of cones with a raster-scanning adaptive optics OCT are highly repeatable.Biomedical optics express · 2026Article
- Evaluating Human Rod Photoreceptor Function Using Pixelwise Intensity-Based Optoretinography.Translational vision science & technology · 2026Article
- ƒ(Cell): Software for Reproducible Analysis of Optoretinograms.Translational vision science & technology · 2026Article
- Optoretinography reveals rapid rod photoreceptor movement upon rhodopsin activation.Light, science & applications · 2026Article
- Structural analysis of cone photoreceptors in AO-OCT enables S-cone identification by a support vector machine classifier.Biomedical optics express · 2026Article
- The Clinical Significance of Imaging Biomarkers Discoverable by Anomaly Detection Methods in Retinal Diseases: A Review.Journal of ophthalmology · 2026Review
- Surpassing the diffraction limit for improved lateral resolution in adaptive optics optical coherence tomography of the living human eye.Communications engineering · 2025Article
- Influence of retinal eccentricity, color blindness, and age on optoretinography measured with AOSLO.Biomedical optics express · 2025Article
- Roadmap on advances in visual and physiological optics.Journal of optics (2010) · 2025Review
- Recent Developments in Photoreceptor Optoretinography and Progress Toward Clinical Use.Translational vision science & technology · 2025Review
- Interferometric imaging of the reversible rhodopsin dynamics in the living rat eye.Nature communications · 2025Article
- Integrated fixation and stimulus channel for adaptive optics ophthalmoscopy.Biomedical optics express · 2025Article
- On the physiological processes underlying optoretinography [Invited].Biomedical optics express · 2025Review
- Measuring Rod- and Cone-Photoreceptor-Specific Vision in Inherited Retinal Diseases Using a Commercial Perimeter.Investigative ophthalmology & visual science · 2025Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Retinitis pigmentosa (RP) is the most common group of inherited retinal degenerative diseases, whose most debilitating phase is cone photoreceptor death. Perimetric and electroretinographic methods are the gold standards for diagnosing and monitoring RP and assessing cone function. However, these methods lack the spatial resolution and sensitivity to assess disease progression at the level of individual photoreceptor cells, where the disease originates and whose degradation causes vision loss. High-resolution retinal imaging methods permit visualization of human cone cells in vivo but have only recently achieved sufficient sensitivity to observe their function as manifested in the cone optoretinogram. By imaging with phase-sensitive adaptive optics optical coherence tomography, we identify a biomarker in the cone optoretinogram that characterizes individual cone dysfunction by stimulating cone cells with flashes of light and measuring nanometer-scale changes in their outer segments. We find that cone optoretinographic responses decrease with increasing RP severity and that even in areas where cone density appears normal, cones can respond differently than those in controls. Unexpectedly, in the most severely diseased patches examined, we find isolated cones that respond normally. Short-wavelength-sensitive cones are found to be more vulnerable to RP than medium- and long-wavelength-sensitive cones. We find that decreases in cone response and cone outer-segment length arise earlier in RP than changes in cone density but that decreases in response and length are not necessarily correlated within single cones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.