Evidence map›Paper›PMID 34795045›Full record

ArticleNeurology2022

Functional Connectivity as a Potential Mechanism for Language Plasticity.

Alyssa S Ailion, Xiaozhen You, Juma S Mbwana, Eleanor J Fanto, Manu Krishnamurthy, Chandan J Vaidya, Leigh N Sepeta, William D Gaillard, Madison M Berl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Noninvasive imaging techniques to map language areas using BOLD signal fluctuations in pediatric epilepsy: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alyssa S AilionFrom the Departments of Psychiatry and Neurology (A.S.A.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Neurology (X.Y., J.S.M., E.J.F., M.K., W.D.G.) and Neuropsychology (L.N.S., M.M.B.), Children's National Hospital; and Department of Psychology (C.J.V.), Georgetown University, Washington, DC. alyssa.ailion@childrens.harvard.edu.ORCID 0000-0001-8974-4169
Xiaozhen YouFrom the Departments of Psychiatry and Neurology (A.S.A.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Neurology (X.Y., J.S.M., E.J.F., M.K., W.D.G.) and Neuropsychology (L.N.S., M.M.B.), Children's National Hospital; and Department of Psychology (C.J.V.), Georgetown University, Washington, DC.ORCID 0000-0003-3592-0985
Juma S MbwanaFrom the Departments of Psychiatry and Neurology (A.S.A.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Neurology (X.Y., J.S.M., E.J.F., M.K., W.D.G.) and Neuropsychology (L.N.S., M.M.B.), Children's National Hospital; and Department of Psychology (C.J.V.), Georgetown University, Washington, DC.ORCID 0000-0003-4382-6155
Eleanor J FantoFrom the Departments of Psychiatry and Neurology (A.S.A.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Neurology (X.Y., J.S.M., E.J.F., M.K., W.D.G.) and Neuropsychology (L.N.S., M.M.B.), Children's National Hospital; and Department of Psychology (C.J.V.), Georgetown University, Washington, DC.
Manu KrishnamurthyFrom the Departments of Psychiatry and Neurology (A.S.A.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Neurology (X.Y., J.S.M., E.J.F., M.K., W.D.G.) and Neuropsychology (L.N.S., M.M.B.), Children's National Hospital; and Department of Psychology (C.J.V.), Georgetown University, Washington, DC.
Chandan J VaidyaFrom the Departments of Psychiatry and Neurology (A.S.A.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Neurology (X.Y., J.S.M., E.J.F., M.K., W.D.G.) and Neuropsychology (L.N.S., M.M.B.), Children's National Hospital; and Department of Psychology (C.J.V.), Georgetown University, Washington, DC.ORCID 0000-0002-8445-7475
Leigh N SepetaFrom the Departments of Psychiatry and Neurology (A.S.A.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Neurology (X.Y., J.S.M., E.J.F., M.K., W.D.G.) and Neuropsychology (L.N.S., M.M.B.), Children's National Hospital; and Department of Psychology (C.J.V.), Georgetown University, Washington, DC.
William D GaillardFrom the Departments of Psychiatry and Neurology (A.S.A.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Neurology (X.Y., J.S.M., E.J.F., M.K., W.D.G.) and Neuropsychology (L.N.S., M.M.B.), Children's National Hospital; and Department of Psychology (C.J.V.), Georgetown University, Washington, DC.
Madison M BerlFrom the Departments of Psychiatry and Neurology (A.S.A.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Neurology (X.Y., J.S.M., E.J.F., M.K., W.D.G.) and Neuropsychology (L.N.S., M.M.B.), Children's National Hospital; and Department of Psychology (C.J.V.), Georgetown University, Washington, DC.

Funding

Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Language and cognition after perinatal strokeR01DC016902 · NIDCD · GEORGETOWN UNIVERSITY · PI GAILLARD, WILLIAM DAVIS, NEWPORT, ELISSA L · 2019 to 2023
$3.0M
Imaging the Impact of Childhood Epilepsy on Memory Development - SupplementK23NS093152 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI SEPETA, LEIGH · 2018 to 2023
$912k
NICHD NIH HHS U54 HD090257NIDCD NIH HHS R01 DC016902NINDS NIH HHS K23 NS093152
6 · The paper itself

Abstract

BACKGROUND AND

objectivesTask fMRI is a clinical tool for language lateralization, but has limitations, and cannot provide information about network-level plasticity. Additional methods are needed to improve the precision of presurgical language mapping. We investigate language resting-state functional connectivity (RS fMRI; FC) in typically developing children (TD) and children with epilepsy. Our objectives were to (1) understand how FC components differ between TD children and those with epilepsy; (2) elucidate how the location of disease (frontal/temporal epilepsy foci) affects FC; and (3) investigate the relationship between age and FC.

methodsOur sample included 55 TD children (mean age 12 years, range 7-18) and 31 patients with focal epilepsy (mean age 13 years, range 7-18). All participants underwent RS fMRI. Using a bilateral canonical language map as target, vertex-wise intrahemispheric FC map and interhemispheric FC map for each participant were computed and thresholded at top 10% to compute an FC laterality index (FCLI; [(L - R)/(L + R)]) of the frontal and temporal regions for both integration (intrahemispheric FC; FCLI

resultsWe found FC differences in the developing language network based on disease, seizure foci location, and age. Frontal and temporal FCLI DISCUSSION: These findings lend preliminary evidence that FC reflects network plasticity in the form of adaptation and compensation, or the ability to recruit support and reallocate resources within and outside of the traditional network to compensate for disease. FC expands on task-based fMRI and provides complementary and potentially useful information about the language network that is not captured using task-based fMRI alone.

Indexed as

Brain MappingLanguageAdolescentChildFunctional LateralityHumansMagnetic Resonance ImagingTemporal Lobe

Identifiers

PMID34795045
PMCPMC8792810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.