ArticleCancer immunology research2022
Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells.
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Article in Cancer immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Unraveling the role of M2 TAMs in ovarian cancer dynamics: a systematic review.Journal of translational medicine · 2025Pooled it
- Pathophysiological roles of monocytes and macrophages in cancer.Nature reviews. Immunology · 2026Review
- Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor-Draining Lymph Nodes of Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-Cell RNA-Sequencing Reveals Tumor Microenvironment Composition and Prior Therapy Modulate Response to Axl Inhibition.Cellular and molecular bioengineering · 2026Article
- Targeting macrophage-driven NK cell immunosuppression to improve cancer immunotherapy.Journal for immunotherapy of cancer · 2026Review
- Positioning and reversible suppression of CCR7Immunity · 2026Article
- From description to prediction: a multi-database bibliometric forecast-validation study of lung cancer and tumor-associated macrophages research (2005-2025).Frontiers in immunology · 2026Review
- Targeting Tumor-Associated Macrophages to Reshape the Immuno-Mechanical Landscape: Molecular Mechanisms and Therapeutic Strategies.International journal of biological sciences · 2026Review
- The emerging role of dendritic cells in the tumor microenvironment: from antigen presentation to targeted immunotherapy.Cell death & disease · 2025Review
- Effect of antibiotics on Kupffer cell immunometabolism relative to intracellular killing ofmBio · 2025Article
- Dendritic cell progenitors engineered to express extracellular-vesicle-internalizing receptors enhance cancer immunotherapy in mouse models.Nature communications · 2025Article
- Emerging therapeutics targeting tumor-associated macrophages for the treatment of solid organ cancers.Expert opinion on emerging drugs · 2025Review
- Convergent inducers and effectors of T cell paralysis in the tumour microenvironment.Nature reviews. Cancer · 2025Review
- Enhancing natural killer cell anti-tumour activity through macrophage manipulation.Frontiers in immunology · 2025Review
- HSP90 promotes tumor associated macrophage differentiation during triple-negative breast cancer progression.Scientific reports · 2024Article
- Review
- Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy.Nature cancer · 2024Article
- Spatial distribution of tumor-associated macrophages in an orthotopic prostate cancer mouse model.Pathology oncology research : POR · 2024Article
- Mapping the landscape and exploring trends in macrophage-related research within non-small cell lung cancer: a comprehensive bibliometric analysis.Frontiers in immunology · 2024Article
- Dendritic cells as shepherds of T cell immunity in cancer.Immunity · 2023Review
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Authors and funding
22 authors at 5 institutions in 3 countries.
Christina PfirschkeCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-9434-4485
Rapolas ZilionisDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts.
Camilla EngblomCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Marius MessemakerCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Angela E ZouCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Steffen RickeltDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.ORCID 0000-0002-5224-7764
Nicolas A Gort-FreitasDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-8614-4782
Yunkang LinCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Ruben BillCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Marie SiwickiCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Jeremy GungabeesoonCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-4505-3160
Melissa M SprachmanCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-8227-378X
Angela N MarquardCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Christopher B RodellCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-2168-0802
Michael F CuccareseCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Jeremy QuintanaCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Maaz S AhmedCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-9558-5790
Rainer H KohlerCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-6269-6590
Virginia SavovaDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts.
Ralph WeisslederCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts.
Allon M KleinDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts. mikael.Pittet@unige.ch allon_klein@hms.harvard.edu.ORCID 0000-0001-8913-7879
Mikael J PittetCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, Massachusetts. mikael.Pittet@unige.ch allon_klein@hms.harvard.edu.
Center for Systems Biology · USHarvard University · USMassachusetts General Hospital · USMassachusetts Institute of Technology · USUniversity of Geneva · CH
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MCellular mechanisms by which exhausted T cell responses are restoredR01AI123349 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Thorsten Roman Mempel · 2017 to 2026
$4.5MIn vivo behavior of monocytes in resting and inflammatory conditionsR01AI084880 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PITTET, MIKAEL · 2011 to 2020
$4.4MThe Extracellular Matrix in Tumor Progression and MetastasisU54CA163109 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEINBERG, ROBERT A · 2011 to 2015
$3.7MImaging of nanotherapeutic drug actionU01CA206997 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2017 to 2021
$2.9MSingle Cell Genome-Wide Myeloid Response Profiling in ImmunotherapyR01CA218579 · NCI · HARVARD MEDICAL SCHOOL · PI KLEIN, ALLON MOSHE, PITTET, MIKAEL · 2018 to 2022
$2.7MImaging tumor associated macrophage (TAM) functionR01CA206890 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PITTET, MIKAEL, WEISSLEDER, MD, PHD, RALPH · 2017 to 2021
$1.9MAnalysis of scant cancer cells in fine needle aspiratesR33CA202064 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2016 to 2018
$1.3MNCI NIH HHS R01 CA206890NCI NIH HHS R01 CA218579NCI NIH HHS R33 CA202064NCI NIH HHS U01 CA206997NCI NIH HHS U54 CA163109NIAID NIH HHS R01 AI084880NIAID NIH HHS R01 AI123349NIGMS NIH HHS T32 GM007753
Abstract
Macrophages often abound within tumors, express colony-stimulating factor 1 receptor (CSF1R), and are linked to adverse patient survival. Drugs blocking CSF1R signaling have been used to suppress tumor-promoting macrophage responses; however, their mechanisms of action remain incompletely understood. Here, we assessed the lung tumor immune microenvironment in mice treated with BLZ945, a prototypical small-molecule CSF1R inhibitor, using single-cell RNA sequencing and mechanistic validation approaches. We showed that tumor control was not caused by CSF1R
Indexed as
AnimalsBenzothiazolesCell Line, TumorDendritic CellsFemaleImmunotherapyInterferon-gammaInterleukin-12Lung NeoplasmsMiceMice, Inbred C57BLPicolinic AcidsTumor-Associated MacrophagesTumor MicroenvironmentXenograft Model Antitumor Assays4-(2-(2-hydroxycyclohexylamino)benzothiazol-6-yloxy)pyridine-2-carboxylic acid methylamideBenzothiazolesInterferon-gammaInterleukin-12Picolinic Acids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.