Evidence map›Paper›PMID 34794948›Full record

ArticleAJNR. American journal of neuroradiology2022

Reduced Leukoaraiosis, Noncardiac Embolic Stroke Etiology, and Shorter Thrombus Length Indicate Good Leptomeningeal Collateral Flow in Embolic Large-Vessel Occlusion.

T Hashimoto, T Kunieda, T Honda, F Scalzo, L Ali, J D Hinman, N M Rao, M Nour, M Bahr-Hosseini, J L Saver and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

T HashimotoFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California tetsuyahashimoto629@hotmail.co.jp.ORCID 0000-0002-8121-0215
T KuniedaFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-3672-4305
T HondaFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-9999-230X
F ScalzoFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-9755-8104
L AliFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0003-4132-2260
J D HinmanFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-0872-5044
N M RaoFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-7043-2675
M NourFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-5493-9679
M Bahr-HosseiniFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0003-3049-4542
J L SaverFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-9141-2251
R RaychevFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0001-8463-0664
D LiebeskindFrom the Department of Neurology and Comprehensive Stroke Center, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0002-5109-8736
University of California, Los Angeles · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAcute leptomeningeal collateral flow is vital for maintaining perfusion to penumbral tissue in acute ischemic stroke caused by large-vessel occlusion. In this study, we aimed to investigate the clinically available indicators of leptomeningeal collateral variability in embolic large-vessel occlusion. MATERIALS AND

methodsAmong prospectively registered consecutive patients with acute embolic anterior circulation large-vessel occlusion treated with thrombectomy, we analyzed 108 patients admitted from January 2015 to December 2019 who underwent evaluation of leptomeningeal collateral status on pretreatment CTA. Clinical characteristics, extent of leukoaraiosis on MR imaging, embolic stroke subtype, time of imaging, occlusive thrombus characteristics, presenting stroke severity, and clinical outcome were collected. The clinical indicators of good collateral status (>50% collateral filling of the occluded territory) were analyzed using multivariate logistic regression analysis.

resultsGood collateral status was present in 67 patients (62%) and associated with independent functional outcomes at 3 months. Reduced leukoaraiosis (total Fazekas score, 0-2) was positively related to good collateral status (OR, 9.57; 95% CI, 2.49-47.75), while the cardioembolic stroke mechanism was inversely related to good collateral status (OR, 0.17; 95% CI, 0.02-0.87). In 82 patients with cardioembolic stroke, shorter thrombus length (OR, 0.91 per millimeter increase; 95% CI, 0.82-0.99) and reduced leukoaraiosis (OR, 5.79; 95% CI, 1.40-29.61) were independently related to good collateral status.

conclusionsAmong patients with embolic large-vessel occlusion, reduced leukoaraiosis, noncardiac embolism mechanisms including embolisms of arterial or undetermined origin, and shorter thrombus length in cardioembolism are indicators of good collateral flow.

Indexed as

Brain IschemiaEmbolic StrokeEmbolismIschemic StrokeLeukoaraiosisStrokeThrombosisCollateral CirculationHumansRetrospective Studies

Identifiers

PMID34794948
PMCPMC8757540
OpenAlexW3213607056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.