ArticleAJNR. American journal of neuroradiology2022
An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension.
Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 54 citations in OpenAlex.
- Change in Amyloid-β Deposition and Diffusion Tensor Image Analysis along the Perivascular Space Index in Incident Neurodegenerative Disease.Annals of neurology · 2026Article
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- Associations of Cognitive Impairment with Putative Glymphatic-Related Imaging Indices and Cortical Atrophy in Cerebral Amyloid Angiopathy.Biomedicines · 2026Article
- Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS.Frontiers in neuroscience · 2026Article
- Glymphatic dysfunction as an imaging biomarker for cognitive impairment in patients with β-thalassemia major: A multimodal MRI study.European journal of radiology open · 2025Article
- Blood pressure dynamic instability and neurodegeneration in older adults.Journal of Alzheimer's disease : JAD · 2025Article
- MRI Evaluation of Glymphatic Dysfunction in Cerebral Small Vessel Disease: Hypertensive vs. Normotensive Patients.The European journal of neuroscience · 2025Article
- MR Imaging Indices for Brain Interstitial Fluid Dynamics and the Effects of Orexin Antagonists on Sleep.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Glymphatic system dysfunction in alcohol use disorder: Current understanding and future directions.World journal of psychiatry · 2025Review
- Aortic Stiffness and Alzheimer's Disease: The Medin Connection.Biomolecules · 2025Review
- Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function.Alzheimer's research & therapy · 2025Article
- Decoding Brain Development and Aging: Pioneering Insights From MRI Techniques.Investigative radiology · 2025Review
- Glymphatic system in neurological disorders and implications for brain health.Frontiers in neurology · 2025Article
- Perivascular space diffusivity and brain microstructural measures are associated with circadian time and sleep quality.Journal of sleep research · 2024Article
- Decreased diffusivity along the perivascular space and cerebral hemodynamic disturbance in adult moyamoya disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements.NMR in biomedicine · 2024Review
- Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- The glymphatic system and cerebral small vessel disease.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Review
- Overview of the Current Knowledge and Conventional MRI Characteristics of Peri- and Para-Vascular Spaces.Brain sciences · 2024Review
- Association between the Putative Meningeal Lymphatics at the Posterior Wall of the Sigmoid Sinus and Delayed Contrast-agent Elimination from the Cerebrospinal Fluid.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeHypertension may be related to alterations of the glymphatic system, a waste metabolite drainage system in the brain. We aimed to investigate analysis along the perivascular space index changes in elderly subjects with hypertension. MATERIALS AND
methodsDiffusion-weighted images were acquired from 126 subjects, including 63 subjects with hypertension (25 men and 38 women; mean age, 72.45 years) and 63 age- and sex-matched controls (25 men and 38 women; mean age, 72.16 years). We calculated the analysis along the perivascular space index as a ratio of the mean of x-axis diffusivities in the projection and association areas to the mean of y-axis diffusivity in the projection area and z-axis diffusivity in the association area. The left, right, and mean analysis along the perivascular space indices of both hemispheres were compared between the hypertension and control groups using a Mann-Whitney
resultsThe left (
conclusionsOur results are consistent with a model in which hypertension causes glymphatic dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.