Evidence map›Paper›PMID 34794792›Full record

ArticleHematology, transfusion and cell therapy2021

Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. III: anti-CD19 CAR-T cell therapy for patients with non-Hodgkin lymphoma.

Alvaro J Alencar, Alexandre V Hirayama, Diego V Clé, Marco Aurélio Salvino, Guilherme Perini, Celso Arrais, Otávio Baiocchi, Leonardo Carvalho Palma, Iago Colturato, Jorge Vaz and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Hematology, transfusion and cell therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. CAR T-cell therapy and the onco-nephrologist.Frontiers in nephrology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 16 institutions in 2 countries.

Alvaro J AlencarSylvester Comprehensive Cancer Center, Universidade de Miami Miller School of Medicine, Miami, FL, USA.
Alexandre V HirayamaFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Diego V CléFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
Marco Aurélio SalvinoHospital Universitário Prof. Edgard Santos, Salvador, BA, Brazil.
Guilherme PeriniHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Celso ArraisUniversidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil; Hospital Sírio-Libanês, São Paulo, SP, Brazil.
Otávio BaiocchiHospital Sírio-Libanês, São Paulo, SP, Brazil; Hospital Alemão Oswaldo Cruz, São Paulo, SP, Brazil.
Leonardo Carvalho PalmaHospital das Clínicas da Faculdade de Medicina de Ribeirão Preto (HCFMRP-USP), Ribeirão Preto, SP, Brazil.
Iago ColturatoHospital Amaral Carvalho, Jaú, SP, Brazil.
Jorge VazCentro de Câncer de Brasilia (CETTRO), Brasilia, DF, Brazil.
Ricardo ChiattoneHospital Samaritano de São Paulo, São Paulo, SP, Brazil.
Marcos de LimaOhio State University, Columbus, OH, USA.
Jayr Schmidt FilhoA.C.Camargo Cancer Center,São Paulo, SP, Brazil.
Samir NabhanHospital de Clínicas - Universidade Federal do Paraná, (HC UFPR), Curitiba, PR, Brazil.
Vanderson RochaHospital das Clínicas, Universidade de São Paulo, (HC USP), São Paulo, SP, Brazil; Hospital Vila Nova Star, São Paulo, SP, Brazil.
Renato L Guerino-CunhaFaculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
Carlos S ChiattoneFaculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), São Paulo, SP, Brazil. Electronic address: carlos.chiattone@terra.com.br.
Universidade de Ribeirão Preto · BRAC Camargo Hospital · BRClinics Hospital of Ribeirão Preto · BRComplexo Hospitalar Universitário Professor Edgard Santos · BRFaculdade de Ciências Médicas da Santa Casa de São Paulo · BRFred Hutch Cancer Center · USHospital Alemão Oswaldo Cruz · BRHospital Amaral Carvalho · BRHospital de Clínicas Universidade Federal do Paraná · BRHospital Israelita Albert Einstein · BRHospital Samaritano de São Paulo · BRHospital Sírio-Libanês · BRHospital Universitário da Universidade de São Paulo · BRSylvester Comprehensive Cancer Center · USThe Ohio State University · USUniversidade de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment and evolution of B-cell non-Hodgkin lymphoma (B-NHL) has undergone important changes in the last years with the emergence of targeted therapies, such as monoclonal antibodies, small molecules, antibody-drug conjugates, and bispecific antibodies. Nevertheless, a significant portion of patients remains refractory or relapsed (R/R) to the new therapeutic modalities, representing thus an unmet medical need. The use of CAR-T cells for the treatment of B-NHL patients has shown to be a promising therapy with impressive results in patients with R/R disease. The expectations are as high as the imminent approval of CAR-T cell therapy in Brazil, which it is expected to impact the prognosis of R/R B-NHL. The aim of this manuscript is to offer a consensus of specialists in the field of onco-hematology and cellular therapy, working in Brazil and United States, in order to discuss and offer recommendations in the present setting of the use of CAR-T cells for patients with B-NHL.

Indexed as

Adoptive cellular therapyAdvanced cellular therapyCAR-T cellsCellular therapyImmunotherapyNon-Hodgkin lymphoma

Identifiers

PMID34794792
PMCPMC8606699
OpenAlexW3214469845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.