ArticleMolecular brain2021
Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice.
Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- The NALCN channel complex is necessary for stabilizing sleep in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2026Article
- Adolescent Insomnia Disorder - Problematic Internet Use Nexus: A Convergent Developmental Trajectory - Bridging Neuroimaging Biomarkers, Molecular Susceptibility, and Environmental-Neurocognitive Cascades.Psychology research and behavior management · 2026Review
- Association between sleep disorders and myopia in Shanghai adolescents: a cross-sectional survey conducted among junior school students.BMC ophthalmology · 2025Article
- Why is vestibular migraine associated with many comorbidities?Journal of neurology · 2024Review
- Multiple ultradian rhythms of metabolism, body temperature and activity in Djungarian hamsters.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- The Mind After Midnight: Nocturnal Wakefulness, Behavioral Dysregulation, and Psychopathology.Frontiers in network physiology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyrosine hydroxylase and its specific rescue in noradrenergic and adrenergic neurons. We found that DD mice have reduced time spent in wakefulness. Unexpectedly, DD mice also exhibited a marked reduction in the time spent in rapid eye movement (REM) sleep. The electroencephalogram power spectrum of all vigilance states in DD mice were also affected. These results support the current understanding of the critical roles of the dopaminergic system in maintaining wakefulness and also implicate its previously unknown effects on REM sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.