Evidence map›Paper›PMID 34794338›Full record

ArticleCirculation. Arrhythmia and electrophysiology2021

Making Heads or Tails of the Large Mammalian Sinoatrial Node Micro-Organization.

Regan L Smithers, Hillary K J Kao, Sarah Zeigler, Sergey Yechikov, Jan A Nolta, James W Chan, Nipavan Chiamvimonvat, Deborah K Lieu

Abstract readLetter
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Aging and sinus node dysfunction: mechanisms and future directions.Clinical science (London, England : 1979) · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Regan L Smithers *Department of Internal Medicine, Division of Cardiovascular Medicine (R.L.S., H.K.J.K., N.C., D.K.L.), University of California, Davis.
Hillary K J Kao *Department of Internal Medicine, Division of Cardiovascular Medicine (R.L.S., H.K.J.K., N.C., D.K.L.), University of California, Davis.ORCID 0000-0002-0849-8507
Sarah ZeiglerInstitute for Regenerative Cures and Stem Cell Program, University of California Davis Health Systems (R.L.S., H.K.J.K., S.Z., J.A.N., D.K.L.).
Sergey YechikovDepartment of Biomedical Engineering (S.Y.), University of California, Davis.
Jan A NoltaInstitute for Regenerative Cures and Stem Cell Program, University of California Davis Health Systems (R.L.S., H.K.J.K., S.Z., J.A.N., D.K.L.).
James W ChanDepartment of Pathology and Laboratory Medicine (J.W.C.), University of California, Davis.
Nipavan ChiamvimonvatDepartment of Internal Medicine, Division of Cardiovascular Medicine (R.L.S., H.K.J.K., N.C., D.K.L.), University of California, Davis.ORCID 0000-0001-9499-8817
Deborah K LieuDepartment of Internal Medicine, Division of Cardiovascular Medicine (R.L.S., H.K.J.K., N.C., D.K.L.), University of California, Davis.ORCID 0000-0002-3765-3203

Funding

Functional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3M
Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Translational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7M
Decoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2M
Regulation of ion channels in the heartI01BX000576 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI CHIAMVIMONVAT, NIPAVAN · 2009 to 2019
–
Metabolomics study in patients post myocardial infarctionI01CX001490 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2021
–
BLRD VA I01 BX000576CSRD VA I01 CX001490NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL137228NHLBI NIH HHS T32 HL086350
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biological ClocksAction PotentialsAnimalsBiomarkersHeartHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMyocytes, CardiacSinoatrial NodeSus scrofaTroponin TVimentinBiomarkersHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsTroponin TVimentincardiac myocyteselectrophysiologymammalssinoatrial node

Identifiers

PMID34794338
PMCPMC8692394

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.