Evidence map›Paper›PMID 34793753›Full record

ArticleThe American journal of medicine2022

Differences in Inflammation, Treatment, and Outcomes Between Black and Non-Black Patients Hospitalized for COVID-19: A Prospective Cohort Study.

Tariq U Azam, Hanna Berlin, Elizabeth Anderson, Michael Pan, Husam R Shadid, Kishan Padalia, Patrick O'Hayer, Chelsea Meloche, Rafey Feroze, Erinleigh Michaud and 7 more

2 registry-linked trialsOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04706533 completednot on this map

Prospective Observational Study Examining Clinical Characteristics, Inflammatory Markers, Treatments and Outcomes of Patients Hospitalized for COVID-19 at the University of Michigan Healthcare System in Ann Arbor

TypeobservationalSponsorUniversity of MichiganRan2020 to 2022Enrolled3,402ConditionsCovid19, Kidney Diseases, Inflammation, SARS-CoV InfectionArmsBiomarkers of inflammation
NCT04818866 completednot on this map

The International Study of Inflammation in COVID-19: A Prospective Multi-Center Observational Study Examining the Role of Biomarkers of Inflammation in Predicting Covid-19 Related Outcomes in Hospitalized Patients

TypeobservationalSponsorUniversity of MichiganRan2020 to 2022Enrolled4,463ConditionsCovid19, Outcome, Fatal, Respiratory Failure, Acute Kidney InjuryArmsSuPAR, C-reactive protein, Ferritin, D-Dimer, Procalcitonin, Interleukin-6, Lactate Dehydrogenase
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Tariq U AzamDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor.
Hanna BerlinUniversity of Michigan Medical School, Ann Arbor.
Elizabeth AndersonDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor.
Michael PanDepartment of Internal Medicine, University of Michigan, Ann Arbor.
Husam R ShadidDepartment of Internal Medicine, University of Michigan, Ann Arbor.
Kishan PadaliaDepartment of Internal Medicine, University of Michigan, Ann Arbor.
Patrick O'HayerDepartment of Internal Medicine, University of Michigan, Ann Arbor.
Chelsea MelocheDepartment of Internal Medicine, University of Michigan, Ann Arbor.
Rafey FerozeDepartment of Internal Medicine, University of Michigan, Ann Arbor.
Erinleigh MichaudDepartment of Internal Medicine, University of Michigan, Ann Arbor.
Christopher LauniusDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor.
Penelope BlakelyDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor.
Abbas BitarDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor.
Cristen WillerDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor.
Rodica Pop-BusuiDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor MI, USA.
John M CarethersDivision of Gastroenterology & Hepatology, Department of Internal Medicine and Department of Human Genetics, University of Michigan, Ann Arbor.
Salim S HayekDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor. Electronic address: shayek@med.umich.edu.
University of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
NIDDK Diabetic Foot Consortium Clinical Research UnitU01DK119083 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RODICA BUSUI (POP-BUSUI), Crystal Murray Holmes · 2018 to 2026
$5.5M
The KIDCOV Study: Assessment of Kidney Injury and Associated Risk Factors for SARS-CoV-2R01DK109720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REISER, JOCHEN, SARWAL, MINNIE M · 2017 to 2021
$3.2M
Targeting Inflammation with Salsalate as a Novel Therapy for Diabetic NeuropathyR01DK107956 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUSUI (POP-BUSUI), RODICA, FELDMAN, EVA LUCILLE · 2016 to 2020
$3.0M
Role of SuPAR in the Intersection between Cardiovascular and Kidney DiseaseR01HL153384 · NHLBI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HAYEK, SALIM · 2020 to 2024
$2.5M
Extracorporeal SuPAR Extraction to Prevent COVID-19-associated Acute Kidney InjuryR01DK128012 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAYEK, SALIM · 2021 to 2021
$327k
NHLBI NIH HHS R01 HL153384NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK107956NIDDK NIH HHS R01 DK109720NIDDK NIH HHS R01 DK128012NIDDK NIH HHS U01 DK119083NIDDK NIH HHS U2C DK110768
6 · The paper itself

Abstract

purposeRacial disparities in coronavirus disease 2019 (COVID-19) outcomes have been described. We sought to determine whether differences in inflammatory markers, use of COVID-19 therapies, enrollment in clinical trials, and in-hospital outcomes contribute to racial disparities between Black and non-Black patients hospitalized for COVID-19.

methodsWe leveraged a prospective cohort study that enrolled 1325 consecutive patients hospitalized for COVID-19, of whom 341 (25.7%) were Black. We measured biomarkers of inflammation and collected data on the use COVID-19-directed therapies, enrollment in COVID-19 clinical trials, mortality, need for renal replacement therapy, and need for mechanical ventilation.

resultsCompared to non-Black patients, Black patients had a higher prevalence of COVID-19 risk factors including obesity, hypertension, and diabetes mellitus and were more likely to require renal replacement therapy (15.8% vs 7.1%, P < .001) and mechanical ventilation (37.2% vs 26.6%, P < .001) during their hospitalization. Mortality was similar between both groups (15.5% for Blacks vs 14.0% for non-Blacks, P = .49). Black patients were less likely to receive corticosteroids (44.9% vs 63.8%, P< .001) or remdesivir (23.8% vs 57.8%, P < .001) and were less likely to be enrolled in COVID-19 clinical trials (15.3% vs 28.2%, P < .001). In adjusted analyses, Black race was associated with lower levels of C-reactive protein and soluble urokinase receptor and higher odds of death, mechanical ventilation, and renal replacement therapy. Differences in outcomes were not significant after adjusting for use of remdesivir and corticosteroids.

conclusionsRacial differences in outcomes of patients with COVID-19 may be related to differences in inflammatory response and differential use of therapies.

Indexed as

Black or African AmericanAdultAgedCohort StudiesCOVID-19FemaleHealthcare DisparitiesHealth Status DisparitiesHospitalizationHumansInflammationMaleMiddle AgedProspective StudiesTreatment OutcomeAfrican AmericansConvalescent serumCoronavirusCorticosteroidsDisparitiesM2C2RemdesivirSARS-COV-2

Identifiers

PMID34793753
PMCPMC8592847
OpenAlexW3212871845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.