Evidence map›Paper›PMID 34793703›Full record

ArticleNeuron2021

Dynorphin, won't you myelinate my neighbor?

Xiaoyun Ding, Matthew N Rasband

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Xiaoyun DingDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Matthew N RasbandDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: rasband@bcm.edu.

Funding

The Molecular Architecture of Axons in Health and DiseaseR35NS122073 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW N RASBAND · 2021 to 2026
$5.6M
Oligodendroglial isoforms of ANK3 and their role in CNS functionR01MH121544 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW N RASBAND · 2020 to 2026
$2.6M
NIMH NIH HHS R01 MH121544NINDS NIH HHS R35 NS122073
6 · The paper itself

Abstract

Accumulating evidence supports the prevalence of experience-dependent oligodendrocyte precursor cell (OPC) differentiation and myelination in learning and memory. However, the mechanisms remain unknown. In this issue of Neuron, Osso et al., (2021) report that stress causes the secretion of dynorphin by unmyelinated axons, which induces OPC differentiation and myelination of neighboring axons.

Indexed as

DynorphinsOligodendrocyte Precursor CellsAxonsCell DifferentiationOligodendrogliaDynorphins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.