Article in PLoS pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors at 3 institutions in 1 country.
Roslyn A TaylorDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.ORCID 0000-0002-3468-0767
Michael D McRavenDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.ORCID 0000-0002-3098-1394
Ann M CariasDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.ORCID 0000-0003-1305-254X
Meegan R AndersonDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Edgar MatiasDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.ORCID 0000-0002-8345-2840
Mariluz AraíngaDepartment of Biology, New Iberia Research Center, University of Louisiana at Lafayette, Lafayette, Louisiana, United States of America.ORCID 0000-0002-4533-5854
Edward J AllenDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.ORCID 0000-0001-6477-648X
Kenneth A RogersDepartment of Biology, New Iberia Research Center, University of Louisiana at Lafayette, Lafayette, Louisiana, United States of America.ORCID 0000-0002-3911-035X
Sandeep GuptaDepartment of Microbiology, Immunology, and Molecular Genetics, University of Texas Health San Antonio, San Antonio, Texas, United States of America.ORCID 0000-0003-0977-1584
Viraj KulkarniDisease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, Texas, United States of America.ORCID 0000-0002-2094-360X
Samir LakhasheDepartment of Microbiology, Immunology, and Molecular Genetics, University of Texas Health San Antonio, San Antonio, Texas, United States of America.
Ramon Lorenzo-RedondoDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.ORCID 0000-0002-5462-9483
Yanique ThomasDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.ORCID 0000-0003-0602-7493
Amanda StricklandDisease Intervention and Prevention, Texas Biomedical Research Institute, San Antonio, Texas, United States of America.ORCID 0000-0001-5839-2391
Francois J VillingerDepartment of Biology, New Iberia Research Center, University of Louisiana at Lafayette, Lafayette, Louisiana, United States of America.
Ruth M RuprechtDepartment of Biology, New Iberia Research Center, University of Louisiana at Lafayette, Lafayette, Louisiana, United States of America.
Thomas J HopeDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.ORCID 0000-0001-7183-8319
Northwestern University · USTexas Biomedical Research Institute · USUniversity of Louisiana at Lafayette · US
Funding
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Do Early Maternal Antibodies Facilitate Oral Transmission of HIV in Infants?R01DE023049 · NIDCR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI RUPRECHT, RUTH MARGRIT · 2012 to 2016
$4.5M
Understanding the mechanism(s) of systemic antibody delivery, distribution, and localization to mucosal sites in the in vivo macaque modelK01OD026571 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARIAS, ANN M · 2018 to 2020
Vertical transmission of human immunodeficiency virus (HIV) can occur in utero, during delivery, and through breastfeeding. We utilized Positron Emission Tomography (PET) imaging coupled with fluorescent microscopy of 64Cu-labeled photoactivatable-GFP-HIV (PA-GFP-BaL) to determine how HIV virions distribute and localize in neonatal rhesus macaques two and four hours after oral viral challenge. Our results show that by four hours after oral viral exposure, HIV virions localize to and penetrate the rectal mucosa. We also used a dual viral challenge with a non-replicative viral vector and a replication competent SHIV-1157ipd3N4 to examine viral transduction and dissemination at 96 hours. Our data show that while SHIV-1157ipd3N4 infection can be found in the oral cavity and upper gastrointestinal (GI) tract, the small and large intestine contained the largest number of infected cells. Moreover, we found that T cells were the biggest population of infected immune cells. Thus, thanks to these novel technologies, we are able to visualize and delineate of viral distribution and infection throughout the entire neonatal GI tract during acute viral infection.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Localization of infection in neonatal rhesus macaques after oral viral challenge. · full record | OpenQuestion