Evidence map›Paper›PMID 34793268›Full record

ArticleAutophagy2022

Adaptation to hypoxia in

Ayelén Valko, Sebastián Perez-Pandolfo, Eleonora Sorianello, Andreas Brech, Pablo Wappner, Mariana Melani

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Studying Cellular Senescence Using the Model Organism Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. The Pupa Stage Is the Most Sensitive to Hypoxia inInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ayelén ValkoFundación Instituto Leloir, Buenos Aires, Argentina.
Sebastián Perez-PandolfoFundación Instituto Leloir, Buenos Aires, Argentina.
Eleonora SorianelloConsejo Nacional De Investigaciones Científicas Y Técnicas (CONICET), Buenos Aires, Argentina.
Andreas BrechCentre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Pablo WappnerFundación Instituto Leloir, Buenos Aires, Argentina.
Mariana MelaniFundación Instituto Leloir, Buenos Aires, Argentina.ORCID 0000-0002-9491-932X
Consejo Nacional de Investigaciones Científicas y Técnicas · ARFundación Instituto Leloir · AROslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macroautophagy/autophagy, a mechanism of degradation of intracellular material required to sustain cellular homeostasis, is exacerbated under stress conditions like nutrient deprivation, protein aggregation, organelle senescence, pathogen invasion, and hypoxia, among others. Detailed

Indexed as

Drosophila ProteinsSaccharomyces cerevisiae ProteinsAnimalsAutophagyDrosophilaDrosophila melanogasterHypoxiaPhosphatidylinositolsPhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiaeDrosophila ProteinsFAB1 protein, S cerevisiaePhosphatidylinositolsPhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiae Proteinsstv protein, DrosophilaAutophagosomeautophagyDrosophilahypoxiaoxygenstarvation

Identifiers

PMID34793268
PMCPMC9037493
OpenAlexW3213907096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.