Evidence map›Paper›PMID 34793213›Full record

ArticleScience (New York, N.Y.)2021

Biosynthesis of fluopsin C, a copper-containing antibiotic from

Jon B Patteson, Andrew T Putz, Lizhi Tao, William C Simke, L Henry Bryant, R David Britt, Bo Li

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Copper homeostasis networks in pseudomonas aeruginosa and the organocopper metabolite fluopsin C.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Review
  2. Article
  3. Unlocking a Nitrosuccinate Lyase for Decarboxylative Enzymatic Hydronitration.Angewandte Chemie (International ed. in English) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Heme oxygenase-like dimetal oxidases and oxygenases.Biochemical Society transactions · 2026
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Heme Oxygenase-Like Metalloenzymes.Annual review of biochemistry · 2025
    Review
  19. Review
  20. Biochemical characterization of the self-sacrificing p-aminobenzoate synthase from Nitrosomonas europaea reveals key residues involved in selecting a Fe/Fe or Mn/Fe cofactor.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jon B PattesonDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-5949-7678
Andrew T PutzDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-5427-4096
Lizhi TaoDepartment of Chemistry, University of California, Davis, Davis, CA, USA.ORCID 0000-0001-9921-2297
William C SimkeDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-3016-9969
L Henry BryantDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-6141-6737
R David BrittDepartment of Chemistry, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-0889-8436
Bo LiDepartment of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-8019-8891

Funding

MOLECULAR AND CELLULAR BIOPHYSICS TRAINING PROGRAMT32GM008570 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KUHLMAN, BRIAN A, SLEP, KEVIN C · 1995 to 2022
$5.1M
Supplement:Spectroscopy Investigations of Metalloenzyme MechanismsR35GM126961 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI R. David Britt · 2018 to 2026
$3.7M
Mining Genomes for Synergistic AntibioticsDP2HD094657 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, BO · 2017 to 2017
$2.3M
NICHD NIH HHS DP2 HD094657NIGMS NIH HHS R35 GM126961NIGMS NIH HHS T32 GM008570
6 · The paper itself

Abstract

Metal-binding natural products contribute to metal acquisition and bacterial virulence, but their roles in metal stress response are underexplored. We show that a five-enzyme pathway in

Indexed as

Anti-Bacterial AgentsBacteriaBiosynthetic PathwaysCopperDrug Resistance, BacterialElectron Spin Resonance SpectroscopyGenes, BacterialMicrobial Sensitivity TestsMolecular StructureOperonPseudomonas aeruginosaAnti-Bacterial AgentsCopper

Identifiers

PMID34793213
PMCPMC8939262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.