Evidence map›Paper›PMID 34792825›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2021

Treatment of relapse and survival outcomes after liver transplantation in patients with colorectal liver metastases.

Svein Dueland, Tor M Smedman, Bård Røsok, Harald Grut, Trygve Syversveen, Lars H Jørgensen, Pål-Dag Line

Abstract read
PubMed Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Article
  9. The prognostic value of [Clinical physiology and functional imaging · 2025
    Article
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  17. [Oncological surgery in the interdisciplinary context-On the way to personalized medicine].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2022
    Review
  18. Article
  19. Liver transplantation for colorectal liver metastasis: aiming for a cure or a palliation?Transplant international : official journal of the European Society for Organ Transplantation · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Svein DuelandExperimental Transplantation and Malignancy Research Group, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.ORCID https://orcid.org/0000-0002-6125-6689
Tor M SmedmanDepartment of Oncology, Oslo University Hospital, Oslo, Norway.ORCID https://orcid.org/0000-0002-1531-1229
Bård RøsokDepartment of Hepatobiliary Surgery, Oslo University Hospital, Oslo, Norway.
Harald GrutDepartment of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Trygve SyversveenDepartment of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Lars H JørgensenDepartment of Thoracic Surgery, Oslo University Hospital, Oslo, Norway.
Pål-Dag LineExperimental Transplantation and Malignancy Research Group, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.ORCID https://orcid.org/0000-0002-5884-9336
Oslo University Hospital · NO

Funding

Oslo University HospitalSouth-Eastern Norway Health Authority 39905
6 · The paper itself

Abstract

Liver transplantation (LT) in selected colorectal cancer (CRC) patients with nonresectable liver-only metastases may result in 5-year overall survival of up to about 70-100%. However, the majority will have recurrent disease. All patients included in this report were included in prospective studies. Forty-four out of 56 patients had a relapse, and all 44 patients received treatment for recurrent disease. The organ of the first relapse was lung metastases in 23 of the 44 patients. The first treatment modality of the relapse was the treatment with curative intent in 55.8% of the patients, and chemotherapy was the first treatment administered to 25.6% of the patients. Patients receiving surgery of lung metastases had a 5-year overall survival of 66.5% from the time of metastasectomy. Patients receiving treatment with curative intent for metastases to other organs had a 5-year overall survival of 24.8%. Nine of the 44 patients had no evidence of disease (NED) at the end of the follow-up. Median time of NED in these patients was 54.3 months, and median overall survival from the time of LT was 8.4 years. Because of the high incidence of recurrent disease, these patients should have a systematic long-term follow-up since many of the relapses may be treated with curative intent.

Indexed as

Colorectal NeoplasmsLiver NeoplasmsLiver TransplantationLung NeoplasmsHumansNeoplasm Recurrence, LocalPrognosisProspective StudiesRetrospective StudiesSurvival Ratecolorectal cancerliver transplant recipientsoverall survivaloverall survival after relapsetreatment of relapse

Identifiers

PMID34792825
OpenAlexW3211918484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.