Evidence map›Paper›PMID 34792819›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

B cells support the repair of injured tissues by adopting MyD88-dependent regulatory functions and phenotype.

Ruxandra F Sîrbulescu, Akshay Mamidi, Shu-Yi Claire Chan, Gina Jin, Myriam Boukhali, Don Sobell, Iulian Ilieş, Joon Yong Chung, Wilhelm Haas, Michael J Whalen and 2 more

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Intraparenchymal B cell therapy protects neurological function and modulates local neuroinflammation in experimental hemorrhagic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  7. Article
  8. Review
  9. B cells in non-lymphoid tissues.Nature reviews. Immunology · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. Expansion of B10 cellsInternational journal of molecular medicine · 2025
    Review
  14. Review
  15. Breg-Mediated Immunoregulation in the Skin.International journal of molecular sciences · 2024
    Review
  16. Article
  17. Review
  18. Rag1 Deficiency Impairs Arteriogenesis in Mice.International journal of molecular sciences · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Ruxandra F SîrbulescuVaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-7905-1713
Akshay MamidiVaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Shu-Yi Claire ChanVaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Gina JinVaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Myriam BoukhaliCenter for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Don SobellVaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Iulian IlieşHealthcare Systems Engineering Institute, Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts, USA.
Joon Yong ChungNeuroscience Center, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Wilhelm HaasCenter for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Michael J WhalenNeuroscience Center, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ann E SluderVaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Mark C PoznanskyVaccine and Immunotherapy Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Harvard University · USNortheastern University · US

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6M
Neuroprotective B Cell Immunotherapy for Contusion Traumatic Brain InjuryR01NS117598 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SIRBULESCU, RUXANDRA F · 2021 to 2025
$2.2M
NCI NIH HHS P30 CA006516NINDS NIH HHS R01 NS117598
6 · The paper itself

Abstract

Exogenously applied mature naïve B220

Indexed as

Wound HealingAnimalsB-LymphocytesBrain InjuriesCytokinesInterleukin-10MaleMiceMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88PhenotypeSignal TransductionSkinToll-Like ReceptorsTumor Necrosis Factor-alphaCytokinesIL10 protein, mouseInterleukin-10Myd88 protein, mouseMyeloid Differentiation Factor 88Toll-Like ReceptorsTumor Necrosis Factor-alphaB cellsimmunomodulationinjuryMyD88regulatory mechanismsTLR

Identifiers

PMID34792819
PMCPMC8756564
OpenAlexW3211392543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.