Evidence map›Paper›PMID 34792808›Full record

ReviewCA: a cancer journal for clinicians2022

Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians.

William A Hall, Eric Paulson, X Allen Li, Beth Erickson, Christopher Schultz, Alison Tree, Musaddiq Awan, Daniel A Low, Brigid A McDonald, Travis Salzillo and 3 more

Abstract readHistorical ArticleReview
In one paragraph

Review in CA: a cancer journal for clinicians, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Economic Evaluations of Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  4. Trial
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  7. Materials today. Bio · 2026
    Article
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

William A HallDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.ORCID 0000-0001-7017-6755
Eric PaulsonDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
X Allen LiDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Beth EricksonDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Christopher SchultzDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Alison TreeThe Royal Marsden National Health Service Foundation Trust and the Institute of Cancer Research, London, United Kingdom.
Musaddiq AwanDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Daniel A LowDepartment of Radiation Oncology, University of California-Los Angeles, Los Angeles, California.
Brigid A McDonaldDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0003-4230-1330
Travis SalzilloDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-6271-9879
Carri K Glide-HurstDepartment of Radiation Oncology, University of Wisconsin-Madison, Madison, Wisconsin.
Amar U KishanDepartment of Radiation Oncology, University of California-Los Angeles, Los Angeles, California.
Clifton D FullerDepartment of Radiation Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-5264-3994

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Flexible Hybrid Cloud Infrastructure for Seamless Management of HuBMAP Resources, Including Consortium-Wide and External EngagementOT2OD026675 · OD · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D., SILVERSTEIN, JONATHAN C. · 2018 to 2021
$8.9M
Development of functional magnetic resonance imaging-guided adaptive radiotherapy for head and neck cancer patients using novel MR-Linac deviceR01DE028290 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHRISTODOULEAS, JOHN PAUL, FULLER, CLIFTON DAVID · 2019 to 2023
$4.3M
NRSA Training CoreTL1TR003169 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHANDRA, JOYA, FROST, JEFFREY A. · 2019 to 2023
$3.7M
Institutional Career Development CoreKL2TR001438 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2015 to 2024
$2.9M
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular OsteoradionecrosisR01DE025248 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2016 to 2020
$2.9M
Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer TherapyR01CA258827 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CANAHUATE, GUADALUPE, FULLER, CLIFTON DAVID · 2021 to 2025
$2.9M
Reducing cardiac toxicity with deep learning and MRI-guided radiation therapyR01HL153720 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GLIDE-HURST, CARRI KAYE · 2021 to 2024
$2.2M
SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck CancerR01CA257814 · NCI · RICE UNIVERSITY · PI FULLER, CLIFTON DAVID, SCHAEFER, ANDREW J · 2021 to 2024
$1.8M
Development of Anatomical Patient Models to Facilitate MR-only Treatment PlanningR01CA204189 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI GLIDE-HURST, CARRI KAYE · 2016 to 2020
$1.5M
SMART-ACT: Spatial Methodologic Approaches for Risk Assessment and Therapeutic Adaptation in Cancer TreatmentR01CA214825 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CANAHUATE, GUADALUPE, FULLER, CLIFTON DAVID · 2017 to 2019
$1.1M
imaging Radiation-Associated Dysphagia (iRAD)R01CA218148 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FULLER, CLIFTON DAVID, HUTCHESON, KATHERINE ARNOLD · 2017 to 2019
$810k
Cancer Research UK 28284NCATS NIH HHS KL2 TR001438NCATS NIH HHS TL1 TR003169NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA204189NCI NIH HHS R01 CA214825NCI NIH HHS R01 CA218148NCI NIH HHS R01 CA225190NCI NIH HHS R01 CA257814NCI NIH HHS R01 CA258827NCI NIH HHS R21 CA256144NCI NIH HHS R43 CA254559NHLBI NIH HHS R01 HL153720NIBIB NIH HHS R25 EB025787NIDCR NIH HHS F31 DE029093NIDCR NIH HHS R01 DE025248NIDCR NIH HHS R01 DE028290NIDCR NIH HHS R21 DE031082NIH HHS KL2TR001438NIH HHS OT2 OD026675
6 · The paper itself

Abstract

Radiation therapy (RT) continues to play an important role in the treatment of cancer. Adaptive RT (ART) is a novel method through which RT treatments are evolving. With the ART approach, computed tomography or magnetic resonance (MR) images are obtained as part of the treatment delivery process. This enables the adaptation of the irradiated volume to account for changes in organ and/or tumor position, movement, size, or shape that may occur over the course of treatment. The advantages and challenges of ART maybe somewhat abstract to oncologists and clinicians outside of the specialty of radiation oncology. ART is positioned to affect many different types of cancer. There is a wide spectrum of hypothesized benefits, from small toxicity improvements to meaningful gains in overall survival. The use and application of this novel technology should be understood by the oncologic community at large, such that it can be appropriately contextualized within the landscape of cancer therapies. Likewise, the need to test these advances is pressing. MR-guided ART (MRgART) is an emerging, extended modality of ART that expands upon and further advances the capabilities of ART. MRgART presents unique opportunities to iteratively improve adaptive image guidance. However, although the MRgART adaptive process advances ART to previously unattained levels, it can be more expensive, time-consuming, and complex. In this review, the authors present an overview for clinicians describing the process of ART and specifically MRgART.

Indexed as

Particle AcceleratorsHistory, 20th CenturyHistory, 21st CenturyHumansMagnetic Resonance Imaging, InterventionalNeoplasmsRadiation OncologyRadiotherapy Planning, Computer-Assisted0.35 Tesla MR Guidance1.5 Tesla MR Guidanceadaptive image guidanceadaptive radiation therapymagnetic resonance (MR)-guided radiationpersonalized radiation therapyRT adaptionUnityViewRay

Identifiers

PMID34792808
PMCPMC8985054

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.