Evidence map›Paper›PMID 34792729›Full record

ArticleMolecular biology reports2022

Induction of estrogen receptor β-mediated autophagy sensitizes breast cancer cells to TAD1822-7, a novel biphenyl urea taspine derivative.

Qi Su, Qing Wu, Kun Chen, Jingjing Wang, Ammar Sarwar, Yanmin Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qi SuSchool of Pharmacy, Health Science Center, Shaanxi Province, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, 710061, People's Republic of China.
Qing WuSchool of Pharmacy, Health Science Center, Shaanxi Province, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, 710061, People's Republic of China.
Kun ChenSchool of Pharmacy, Health Science Center, Shaanxi Province, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, 710061, People's Republic of China.
Jingjing WangSchool of Pharmacy, Health Science Center, Shaanxi Province, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, 710061, People's Republic of China.
Ammar SarwarSchool of Pharmacy, Health Science Center, Shaanxi Province, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, 710061, People's Republic of China.
Yanmin ZhangSchool of Pharmacy, Health Science Center, Shaanxi Province, Xi'an Jiaotong University, No. 76, Yanta West Street, #54, Xi'an, 710061, People's Republic of China. zhang2008@xjtu.edu.cn.ORCID http://orcid.org/0000-0001-7307-9408
Xi'an Jiaotong University · CN

Funding

national natural science foundation of china 81773772national natural science foundation of china 81903643
6 · The paper itself

Abstract

backgroundFemale breast cancer has become the most commonly diagnosed cancer worldwide. As a tumor suppressor, estrogen receptor β (ERβ) can be potentially targeted for breast cancer therapy. METHODS AND

resultsTAD1822-7 was evaluated for ERβ-mediated autophagy and cell death using cell proliferation assay, Annexin V/PI staining, immunofluorescence, western blotting, ERβ siRNA, ERβ plasmid transfection and hypoxia cell models. TAD1822-7 upregulated ERβ causing cell death and induced mitochondrial dysfunction and autophagy companied with mitochondrial located ERβ. Enhanced levels of microtubule associated protein1 light chain 3 (LC3)-II and p62/SQSTM1 (p62) indicated that TAD1822-7 blocked the late-stage autolysosome formation, leading to cell death. Mechanistically, TAD1822-7-induced cell death was mediated by phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathways. Moreover, TAD1822-7 modulated hypoxia inducible factor (HIF) functions and autophagy via the inhibition of HIF-1β in the context of hypoxia-induced autophagy. ERβ overexpression and ERβ agonist showed similar effects, whereas ERβ siRNA abrogated TAD1822-7-induced cell death, the inhibition of PI3K/AKT pathway and autophagy. The involvement of PI3K/AKT pathway and autophagy was also demonstrated in TAD1822-7-treated hypoxic breast cancer cells.

conclusionsThese findings provide new insight into the mechanism underlying the inhibitory effects of TAD1822-7 via ERβ-mediated pathways in breast cancer cells.

Indexed as

AlkaloidsAntineoplastic AgentsApoptosisAutophagyBiphenyl CompoundsBreast NeoplasmsCell HypoxiaCell Line, TumorCell ProliferationEstrogen Receptor betaFemaleHumansMorpholinesPhenylurea CompoundsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAKT1 protein, humanAlkaloidsAntineoplastic AgentsbiphenylBiphenyl CompoundsEstrogen Receptor betaMorpholinesPhenylurea CompoundsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTAD1822-7taspineUreaAutophagyBreast cancerCell deathEstrogen receptor βHypoxiaTAD1822-7

Identifiers

PMID34792729
OpenAlexW3201487097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.