Evidence map›Paper›PMID 34792714›Full record

ArticleBulletin of experimental biology and medicine2021

Colony-Forming Ability and Residual Foci of DNA Repair Proteins in Human Lung Fibroblasts Irradiated with Subpicosecond Beams of Accelerated Electrons.

N S Babayan, D V Guryev, N Yu Vorobyeva, B A Grigoryan, G L Tadevosyan, L S Apresyan, A K Chigasova, E I Yashkina, S M Rodneva, A A Tsishnatti and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

N S BabayanInstitute of Molecular Biology, National Academy of Science of the Republic of Armenia, Yerevan, Republic of Armenia.
D V GuryevN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
N Yu VorobyevaN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
B A GrigoryanCANDLE Synchrotron Research Institute, Yerevan, Republic of Armenia.
G L TadevosyanInstitute of Molecular Biology, National Academy of Science of the Republic of Armenia, Yerevan, Republic of Armenia.
L S ApresyanInstitute of Molecular Biology, National Academy of Science of the Republic of Armenia, Yerevan, Republic of Armenia.
A K ChigasovaN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
E I YashkinaA. I. Burnasyan Federal Medical Biophysical Center, Federal Medical-Biological Agency of Russia, Moscow, Russia.
S M RodnevaA. I. Burnasyan Federal Medical Biophysical Center, Federal Medical-Biological Agency of Russia, Moscow, Russia.
A A TsishnattiA. I. Burnasyan Federal Medical Biophysical Center, Federal Medical-Biological Agency of Russia, Moscow, Russia.
Yu A FedotovN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
N K SarkisyanInstitute of Molecular Biology, National Academy of Science of the Republic of Armenia, Yerevan, Republic of Armenia.
A T ManukyanYerevan State University, Yerevan, Republic of Armenia.
R M AroutiounianYerevan State University, Yerevan, Republic of Armenia.
A N OsipovN. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia. andreyan.osipov@gmail.com.
Federal Medical-Biological Agency · RUInstitute of Molecular Biology · AMNational Academy of Sciences of Armenia · AMYerevan State University · AMCenter for the Advancement of Natural Discoveries using Light Emission · AMInstitute of Biochemical Physics NM Emanuel · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a comparative study of the colony-forming ability and the number of residual foci of DNA repair proteins in cultured human lung fibroblasts (MRC-5 cell line) after exposure to subpicosecond beams of accelerated electrons with an energy of 3.6 MeV and quasi-continuous radiation (accelerated electrons with an energy of 4 MeV and X-rays). The yield of damages causing reproductive cell death after pulsed subpicosecond radiation exposure was higher by ~1.8 times than after quasi-continuous radiation exposure. The quantitative yield of residual γH2AX foci (phosphorylated H2AX histone, a protein marker of DNA double breaks) in cells irradiated with subpicosecond beams of accelerated electrons was shown to be ~2.0- 2.5-fold higher than in cells irradiated with quasi-continuous beams of accelerated electrons.

Indexed as

Cell DeathCell LineCell ProliferationDNA Breaks, Double-StrandedDNA Repair EnzymesElectronsFibroblastsHistonesHumansLungDNA Repair EnzymesH2AX protein, humanHistonesaccelerated electronscolony-forming abilitylung fibroblastssubpicosecond radiationγH2AX

Identifiers

PMID34792714
OpenAlexW3190459690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.