Evidence map›Paper›PMID 34792650›Full record

ArticleEuropean child & adolescent psychiatry2023

Stratification of adolescents across mental phenomena emphasizes the importance of transdiagnostic distress: a replication in two general population cohorts.

Jan Stochl, Hannah Jones, Emma Soneson, Adam P Wagner, Golam M Khandaker, Stanley Zammit, Jon Heron, Gemma Hammerton, Edward T Bullmore, Ray Dolan and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European child & adolescent psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Jan StochlDepartment of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK. js883@cam.ac.uk.ORCID http://orcid.org/0000-0002-9693-9930
Hannah JonesCentre for Academic Mental Health, Bristol Medical School, University of Bristol, Bristol, UK.
Emma SonesonDepartment of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK.
Adam P WagnerNational Institute for Health Research Applied Research Collaboration East of England, Cambridge, UK.
Golam M KhandakerDepartment of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK.
Stanley ZammitCentre for Academic Mental Health, Bristol Medical School, University of Bristol, Bristol, UK.
Jon HeronCentre for Academic Mental Health, Bristol Medical School, University of Bristol, Bristol, UK.
Gemma HammertonCentre for Academic Mental Health, Bristol Medical School, University of Bristol, Bristol, UK.
Edward T BullmoreDepartment of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK.
Ray DolanWellcome Trust Centre for Neuroimaging, University College London, London, UK.
Peter FonagyDepartment of Clinical, Educational and Health Psychology, University College London, London, UK.
Ian M GoodyerDepartment of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK.
J PerezDepartment of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK.
Peter B JonesDepartment of Psychiatry, Herchel Smith Building for Brain and Mind Sciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0SZ, UK.
University of Cambridge · GBUniversity of Bristol · GBUniversity of East Anglia · GBCharles University · CZUniversity College London · GBWellcome Centre for Human Neuroimaging · GB

Funding

Medical Research Council MC_G0802534Medical Research Council MC_PC_17213Medical Research Council MR/L010305/1Medical Research Council MR/L022206/1Medical Research Council MR/M006727/1MQ: Transforming Mental Health MQDS17/40Wellcome Trust 095844/Z/11/ZWellcome Trust 201486/Z/16/ZWellcome Trust 209138/Z/17/Z
6 · The paper itself

Abstract

Characterizing patterns of mental phenomena in epidemiological studies of adolescents can provide insight into the latent organization of psychiatric disorders. This avoids the biases of chronicity and selection inherent in clinical samples, guides models of shared aetiology within psychiatric disorders and informs the development and implementation of interventions. We applied Gaussian mixture modelling to measures of mental phenomena from two general population cohorts: the Avon Longitudinal Study of Parents and Children (ALSPAC, n = 3018) and the Neuroscience in Psychiatry Network (NSPN, n = 2023). We defined classes according to their patterns of both positive (e.g. wellbeing and self-esteem) and negative (e.g. depression, anxiety, and psychotic experiences) phenomena. Subsequently, we characterized classes by considering the distribution of diagnoses and sex split across classes. Four well-separated classes were identified within each cohort. Classes primarily differed by overall severity of transdiagnostic distress rather than particular patterns of phenomena akin to diagnoses. Further, as overall severity of distress increased, so did within-class variability, the proportion of individuals with operational psychiatric diagnoses. These results suggest that classes of mental phenomena in the general population of adolescents may not be the same as those found in clinical samples. Classes differentiated only by overall severity support the existence of a general, transdiagnostic mental distress factor and have important implications for intervention.

Indexed as

AnxietyAnxiety DisordersAdolescentChildHumansLongitudinal StudiesParentsAdolescenceClassificationPsychopathologyTransdiagnostic approach

Identifiers

PMID34792650
PMCPMC10147756
OpenAlexW3213020242

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.