Evidence map›Paper›PMID 34792646›Full record

GuidelineArchives of osteoporosis2021

Consensus evidence-based clinical practice guidelines for the diagnosis and treat-to-target management of osteoporosis in Africa: an initiative by the African Society of Bone Health and Metabolic Bone Diseases.

Y El Miedany, Farhanah Paruk, Asgar Kalla, A Adebajo, Maha El Gaafary, Abdellah El Maghraoui, Madeleine Ngandeu, Dzifa Dey, Naglaa Gadallah, Mohamed Elwy and 7 more

Abstract readPractice Guideline
In one paragraph

Guideline in Archives of osteoporosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Article
  5. Long-Term Efficacy and Safety of Denosumab: Insights beyond 10 Years of Use.Endocrinology and metabolism (Seoul, Korea) · 2025
    Review
  6. Review
  7. Developing fracture liaison service framework based on comparative analysis and scoping review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Y El MiedanyCanterbury Christ Church University, Canterbury, UK. yasserelmiedany@gmail.com.ORCID http://orcid.org/0000-0002-4543-692X
Farhanah ParukUniversity of KwaZulu-Natal, Durban, South Africa.ORCID http://orcid.org/0000-0002-2710-899X
Asgar KallaUniversity of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7970-9730
A AdebajoUniversity of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0001-7368-7083
Maha El GaafaryCommunity and Public Health, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0000-0002-3948-3826
Abdellah El MaghraouiMohamed V University, Rabat, Morocco.ORCID http://orcid.org/0000-0003-0668-5680
Madeleine NgandeuFaculty of Medicine and Biomedical Sciences, The University of Yaoundé 1, Yaoundé, Cameroon.ORCID http://orcid.org/0000-0002-0946-9724
Dzifa DeyUniversity of Ghana Medical School, Accra, Ghana.ORCID http://orcid.org/0000-0002-3339-5112
Naglaa GadallahRheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt.
Mohamed ElwyRheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt.
Farzana MoosajeeTygerberg Hospital and Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-6452-9630
Mohammed Hassan Abu-ZaidRheumatology and Rehabiliation, Tanta University, Tanta, Egypt.ORCID http://orcid.org/0000-0001-8436-8598
Salwa GalalRheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0000-0002-5010-2959
Soussen MiladiFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.ORCID http://orcid.org/0000-0002-3596-8025
Waleed HassanRheumatology and Rehabilitation, Benha University, Benha, Egypt.ORCID http://orcid.org/0000-0002-3238-6804
Abubaker FadlelmolaAhmed Gasim Teaching Hospital, Khartoum North, Sudan.
Sally SaberRheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0000-0001-8162-4699

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this consensus statement is to inform the clinical practice communities, research centres and policymakers across Africa of the results of the recommendations for osteoporosis prevention, diagnosis and management. The developed guideline provides state-of-the-art information and presents the conclusions and recommendations of the consensus panel regarding these issues. PURPOSE: To reach an African expert consensus on a treat-to-target strategy, based on current evidence for best practice, for the management of osteoporosis and prevention of fractures.

methodA 3-round Delphi process was conducted with 17 osteoporosis experts from different African countries. All rounds were conducted online. In round 1, experts reviewed a list of 21 key clinical questions. In rounds 2 and 3, they rated the statements stratified under each domain for its fit (on a scale of 1-9). After each round, statements were retired, modified or added in view of the experts' suggestions and the percent agreement was calculated. Statements receiving rates of 7-9 by more than 75% of experts' votes were considered as achieving consensus.

resultsThe developed guidelines adopted a fracture risk-centric approach. Results of round 1 revealed that of the 21 proposed domains, 10 were accepted whereas 11 were amended. In round 2, 32 statements were presented: 2 statements were retired for similarity, 9 statements reached consensus, whereas modifications were suggested for 21 statements. After the 3rd round of rating, the experts came to consensus on the 32 statements. Frequency of high-rate recommendation ranged from 83.33 to 100%. The response rate of the experts was 100%. An algorithm for the osteoporosis management osteoporosis was suggested.

conclusionThis study is an important step in setting up a standardised osteoporosis service across the continent. Building a single model that can be applied in standard practice across Africa will enable the clinicians to face the key challenges of managing osteoporosis; furthermore, it highlights the unmet needs for the policymakers responsible for providing bone health care together with and positive outcomes of patients' care.

Indexed as

Fractures, BoneOsteoporosisBone DensityConsensusDelphi TechniqueHumansAfricaAfrican osteoporosis guidelinesBisphosphonatesDenosumabFallsFRAXGuidelinesOsteoporosisParathyroid hormoneRomosozumab

Identifiers

PMID34792646
PMCPMC8598938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.