Evidence map›Paper›PMID 34792644›Full record

ArticleAmino acids2021

Kinetics of human pyrroline-5-carboxylate reductase in L-thioproline metabolism.

Sagar M Patel, Javier Seravalli, Kyle M Stiers, John J Tanner, Donald F Becker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. The Substrate Versatility of ΔMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sagar M PatelDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID http://orcid.org/0000-0002-1700-3350
Javier SeravalliDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.ORCID http://orcid.org/0000-0001-5619-9424
Kyle M StiersDepartments of Biochemistry and Chemistry, University of Missouri, Columbia, MO, 65211, USA.ORCID http://orcid.org/0000-0001-5542-022X
John J TannerDepartments of Biochemistry and Chemistry, University of Missouri, Columbia, MO, 65211, USA.ORCID http://orcid.org/0000-0001-8314-113X
Donald F BeckerDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA. dbecker3@unl.edu.ORCID http://orcid.org/0000-0002-1350-7201
University of Nebraska–Lincoln · USUniversity of Missouri · US

Funding

Substrate Channeling and Communication in Proline Metabolic EnzymesR01GM065546 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Donald F Becker, JOHN J TANNER · 2002 to 2026
$5.0M
Investigating the Proline Cycle as a Potential Cancer Therapy TargetR01GM132640 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Donald F Becker, JOHN J TANNER · 2020 to 2026
$1.9M
NIGMS NIH HHS R01 GM065546NIGMS NIH HHS R01GM065546NIGMS NIH HHS R01 GM132640NIGMS NIH HHS R01GM132640
6 · The paper itself

Abstract

L-Thioproline (L-thiazolidine-4-carboxylate, L-T4C) is a cyclic sulfur-containing analog of L-proline found in multiple kingdoms of life. The oxidation of L-T4C leads to L-cysteine formation in bacteria, plants, mammals, and protozoa. The conversion of L-T4C to L-Cys in bacterial cell lysates has been attributed to proline dehydrogenase and L-Δ

Indexed as

Binding SitesCysteineHumansKineticsProlinePyrrolesPyrroline Carboxylate ReductasesThiazolidinesCysteinedelta-1-pyrroline-5-carboxylateProlinePyrrolesPyrroline Carboxylate Reductasesthiazolidine-4-carboxylic acidThiazolidinesProduct inhibition kineticsProline biosynthesisSteady-state kineticsThioprolineΔ1-Pyrroline-5-carboxylate reductase

Identifiers

PMID34792644
PMCPMC8876999
OpenAlexW3211947996

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.