Evidence map›Paper›PMID 34792635›Full record

ArticleEuropean radiology2022

Radiation dose reduction with deep-learning image reconstruction for coronary computed tomography angiography.

Dominik C Benz, Sara Ersözlü, François L A Mojon, Michael Messerli, Anna K Mitulla, Domenico Ciancone, David Kenkel, Jan A Schaab, Catherine Gebhard, Aju P Pazhenkottil and 2 more

Open access · hybridAbstract read
In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  17. Misleading Model: Why the 5% Cancer Risk from Computed Tomography Scans Is Overstated.American journal of respiratory and critical care medicine · 2025
    Article
  18. Article
  19. Article
  20. Trading off Iodine and Radiation Dose in Coronary Computed Tomography.Journal of cardiovascular development and disease · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Dominik C BenzDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
Sara ErsözlüDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
François L A MojonDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
Michael MesserliDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
Anna K MitullaDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
Domenico CianconeDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
David KenkelDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
Jan A SchaabDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
Catherine GebhardDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
Aju P PazhenkottilDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
Philipp A KaufmannDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland.
Ronny R BuechelDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, Ramistrasse 100, CH-8091, Zurich, Switzerland. ronny.buechel@usz.ch.
University Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDeep-learning image reconstruction (DLIR) offers unique opportunities for reducing image noise without degrading image quality or diagnostic accuracy in coronary CT angiography (CCTA). The present study aimed at exploiting the capabilities of DLIR to reduce radiation dose and assess its impact on stenosis severity, plaque composition analysis, and plaque volume quantification.

methodsThis prospective study includes 50 patients who underwent two sequential CCTA scans at normal-dose (ND) and lower-dose (LD). ND scans were reconstructed with Adaptive Statistical Iterative Reconstruction-Veo (ASiR-V) 100%, and LD scans with DLIR. Image noise (in Hounsfield units, HU) and quantitative plaque volumes (in mm

resultsReduction of radiation dose from ND scans with ASiR-V 100% to LD scans with DLIR at the highest level (DLIR-H; 1.4 mSv vs. 0.8 mSv, p < 0.001) had no impact on image noise (28 vs. 27 HU, p = 0.598). Reliability of stenosis severity and plaque composition was excellent between ND scans with ASiR-V 100% and LD scans with DLIR-H (intraclass correlation coefficients of 0.995 and 0.974, respectively). Comparison of plaque volumes using Bland-Altman analysis revealed a mean difference of - 0.8 mm

conclusionDLIR enables a reduction in radiation dose from CCTA by 43% without significant impact on image noise, stenosis severity, plaque composition, and quantitative plaque volume. KEY POINTS: •Deep-learning image reconstruction (DLIR) enables radiation dose reduction by over 40% for coronary computed tomography angiography (CCTA). •Image noise remains unchanged between a normal-dose CCTA reconstructed by ASiR-V and a lower-dose CCTA reconstructed by DLIR. •There is no impact on the assessment of stenosis severity, plaque composition, and quantitative plaque volume between the two scans.

Indexed as

Computed Tomography AngiographyDeep LearningAlgorithmsCoronary AngiographyDrug TaperingHumansImage Processing, Computer-AssistedProspective StudiesRadiation DosageRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsCoronary angiographyDeep learningPlaque, AtheroscleroticProspective studiesRadiation dosage

Identifiers

PMID34792635
PMCPMC8921160
OpenAlexW3213353811

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.