ArticleGenome biology and evolution2021
Concurrent Evolution of Antiaging Gene Duplications and Cellular Phenotypes in Long-Lived Turtles.
Article in Genome biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Dissecting cancer in a non-mammalian model: genomic insights from lemon frost geckos.BMC biology · 2026Article
- The genomic basis of independent marine transitions in turtles: convergent episodic adaptation and demographic shifts.Molecular biology and evolution · 2026Article
- Drivers of Thermal Habitat Use in Turtles Studied Under Semi-Natural Conditions.Ecology and evolution · 2026Article
- A comprehensive embryonic staging series of the turtle Trachemys scripta.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Do turtles get cancer?Bioscience · 2025Review
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- Extensive longevity and DNA virus-driven adaptation in nearcticbioRxiv : the preprint server for biology · 2025Article
- Strong Signatures of Selection on Candidate Genes Underlying Core Speciation Mechanisms in Desert Tortoises.Molecular ecology resources · 2025Article
- Assessing CometChip technology for DNA damage studies in non-model species: distinct UV-induced responses in turtles and mammals.BMC research notes · 2025Article
- Genome Assembly ofAnimals : an open access journal from MDPI · 2025Article
- Cancer Prevalence across Vertebrates.Cancer discovery · 2025Article
- Primary Cell Culture as a Model System for Evolutionary Molecular Physiology.International journal of molecular sciences · 2024Review
- The evolution of aging and lifespan.Trends in genetics : TIG · 2023Review
- Cancer Prevalence Across Vertebrates.Research square · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
There are many costs associated with increased body size and longevity in animals, including the accumulation of genotoxic and cytotoxic damage that comes with having more cells and living longer. Yet, some species have overcome these barriers and have evolved remarkably large body sizes and long lifespans, sometimes within a narrow window of evolutionary time. Here, we demonstrate through phylogenetic comparative analysis that multiple turtle lineages, including Galapagos giant tortoises, concurrently evolved large bodies, long lifespans, and reduced cancer risk. We also show through comparative genomic analysis that Galapagos giant tortoises have gene duplications related to longevity and tumor suppression. To examine the molecular basis underlying increased body size and lifespan in turtles, we treated cell lines from multiple species, including Galapagos giant tortoises, with drugs that induce different types of cytotoxic stress. Our results indicate that turtle cells, in general, are resistant to oxidative stress related to aging, whereas Galapagos giant tortoise cells, specifically, are sensitive to endoplasmic reticulum stress, which may give this species an ability to mitigate the effects of cellular stress associated with increased body size and longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.