Evidence map›Paper›PMID 34792431›Full record

ArticleEmerging microbes & infections2021

Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice.

Ji Ma, Robbert Boudewijns, Lorena Sanchez-Felipe, Niraj Mishra, Thomas Vercruysse, Dieudonné Buh Kum, Hendrik Jan Thibaut, Johan Neyts, Kai Dallmeier

Open access · goldAbstract readComparative Study
In one paragraph

Article in Emerging microbes & infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. CD4Nature immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Ji MaKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Rega Institute, Leuven, Belgium.ORCID 0000-0002-0912-2632
Robbert BoudewijnsKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Rega Institute, Leuven, Belgium.ORCID 0000-0002-5984-7279
Lorena Sanchez-FelipeKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Rega Institute, Leuven, Belgium.ORCID 0000-0002-6928-0931
Niraj MishraKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Rega Institute, Leuven, Belgium.ORCID 0000-0002-8679-8847
Thomas VercruysseKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Rega Institute, Leuven, Belgium.ORCID 0000-0002-8649-777X
Dieudonné Buh KumKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Rega Institute, Leuven, Belgium.ORCID 0000-0001-8251-8230
Hendrik Jan ThibautKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Rega Institute, Leuven, Belgium.ORCID 0000-0001-5785-8276
Johan NeytsKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Rega Institute, Leuven, Belgium.ORCID 0000-0002-0033-7514
Kai DallmeierKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery, Rega Institute, Leuven, Belgium.ORCID 0000-0002-8117-9166
Rega Institute for Medical Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The live-attenuated yellow fever 17D (YF17D) vaccine is one of the most efficacious human vaccines and also employed as a vector for novel vaccines. However, in the lack of appropriate immunocompetent small animal models, mechanistic insight in YF17D-induced protective immunity remains limited. To better understand YF17D vaccination and to identify a suitable mouse model, we evaluated the immunogenicity and protective efficacy of YF17D in five complementary mouse models, i.e. wild-type (WT) BALB/c, C57BL/6, IFN-α/β receptor (

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralDisease Models, AnimalFemaleHumansImmunity, CellularImmunity, HumoralMaleMiceMice, Inbred BALB CMice, Inbred C57BLT-LymphocytesVaccines, AttenuatedYellow FeverYellow Fever VaccineAntibodies, NeutralizingAntibodies, ViralVaccines, AttenuatedYellow Fever Vaccinecorrelate of protectionlive-attenuated vaccinemouse modelstype I IFN responseYellow fever 17D

Identifiers

PMID34792431
PMCPMC8648041
OpenAlexW3213108719

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.