Evidence map›Paper›PMID 34792297›Full record

ArticleJournal of diabetes investigation2022

Allogeneic islet transplantation with monitoring of islet-specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report.

Daisuke Chujo, Toshiaki Kurokawa, Akitsu Kawabe, Nobuyuki Takahashi, Fuyuki Inagaki, Koya Shinohara, Shotaro Hagiwara, Yoshihiro Edamoto, Norio Ohmagari, Fumihiko Hinoshita and 6 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Daisuke ChujoPancreatic Islet Transplantation Project, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7727-6310
Toshiaki KurokawaDepartment of Surgery, JCHO Tokyo Takanawa Hospital, Tokyo, Japan.
Akitsu KawabePancreatic Islet Transplantation Project, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Nobuyuki TakahashiDepartment of Diabetes, Endocrinology and Metabolism, National Center for Global health and Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-8592-6528
Fuyuki InagakiHepato-Biliary-Pancreatic Surgery Division, Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan.
Koya ShinoharaPancreatic Islet Transplantation Project, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Shotaro HagiwaraFaculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Yoshihiro EdamotoDepartment of Surgery, Secomedic Hospital, Chiba, Japan.
Norio OhmagariDisease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
Fumihiko HinoshitaNephrology, National Center for Global Health and Medicine, Tokyo, Japan.
Tsuyoshi TajimaRadiology, National Center for Global Health and Medicine, Tokyo, Japan.
Hiroshi KajioDepartment of Diabetes, Endocrinology and Metabolism, National Center for Global health and Medicine, Tokyo, Japan.
Hiroshi OhtsuCenter for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Nobuyuki TakemuraHepato-Biliary-Pancreatic Surgery Division, Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan.
Shinichi MatsumotoPancreatic Islet Transplantation Project, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Masayuki ShimodaPancreatic Islet Transplantation Project, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-0338-0008
National Center for Global Health and Medicine · JPChiba Hospital · JPUniversity of Tokyo Hospital · JPUniversity of Tsukuba · JP

Funding

NCGM Intramural Research Fund 24A002
6 · The paper itself

Abstract

Here, we report a case of allogeneic islet transplantation in Japan. A 48-year-old man received intraportal islet transplantation (5,945 islet equivalent/kg), and stabilization of blood glucose levels and suppression of hypoglycemia were achieved. In the present case, we used our original assessment method to detect the responses of the recipient's T cells to islet autoantigens over time to monitor cellular autoimmunity. Other markers could not predict graft dysfunction in advance, but our method detected the activation of islet antigen-specific CD8

Indexed as

Diabetes Mellitus, Type 1Hematopoietic Stem Cell TransplantationIslets of LangerhansIslets of Langerhans TransplantationAutoimmunityHumansJapanMaleMiddle AgedAutoimmune responseIslet transplantationType 1 diabetes mellitus

Identifiers

PMID34792297
PMCPMC9017629
OpenAlexW3213987735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.